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CORRELATION OF GENE EXPRESSION PROFILE STATUS AND AMERICAN JOINT COMMISSION ON CANCER STAGE IN UVEAL MELANOMA.

Publication ,  Journal Article
Berry, DE; Schefler, AC; Seider, MI; Materin, M; Stinnett, S; Mruthyunjaya, P; Ocular Oncology Study Consortium,
Published in: Retina
February 2020

PURPOSE: To study the relationship between gene expression profile (GEP) subclass and American Joint Committee on Cancer (AJCC) stage in patients with uveal melanoma (UM). METHODS: A retrospective, multicenter study was undertaken with patients entered from nine major ocular oncology centers from across the United States. Three hundred sixty eligible patients had UM and underwent I-125 plaque brachytherapy with concurrent tumor biopsy with GEP testing between January 1, 2010, and October 28, 2014. Patient demographics and UM features were analyzed by both GEP and AJCC status. RESULTS: Gene expression profile class divided the cohort into three groups: Class 1a (n = 186), Class 1b (n = 77), and Class 2 (n = 113). When classified using AJCC staging criteria, we found the following: Stage I in 91 cases (25.3%), Stage IIA in 143 cases (39.7%), Stage IIB in 89 cases (24.7%), Stage IIIA in 36 cases (10%), and Stage IIIB in 1 case (0.3%). There were no Stage IV cases, as lymph node and metastatic data were not collected as a part of this study. Among Stage I tumors, both high tumor height and high largest basal diameter were associated with a higher frequency of Class 2 status (P < 0.05). As UMs progress to a larger AJCC tumor group (T1-T4), the odds ratio of having a worse prognosis based on GEP class was 1.75 (95% CI, 1.36-2.25; P < 0.001). Similarly, as UMs progress to a higher AJCC stage, the odds ratio of having a worse prognosis based on GEP class was 1.69 (95% CI, 1.36-2.10; P < 0.001). CONCLUSION: This report details the differences in clinical features between GEP subclasses and how they are distributed among the AJCC stages. When the tumors were grouped by AJCC staging criteria, both larger AJCC tumor (T) group and worsening AJCC stage were associated with worsening predicted prognosis, based on GEP subclass.

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Published In

Retina

DOI

EISSN

1539-2864

Publication Date

February 2020

Volume

40

Issue

2

Start / End Page

214 / 224

Location

United States

Related Subject Headings

  • Young Adult
  • Uveal Neoplasms
  • United States
  • Societies, Medical
  • Retrospective Studies
  • Ophthalmology & Optometry
  • Ophthalmology
  • Neoplasm Staging
  • Middle Aged
  • Melanoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Berry, D. E., Schefler, A. C., Seider, M. I., Materin, M., Stinnett, S., Mruthyunjaya, P., & Ocular Oncology Study Consortium, . (2020). CORRELATION OF GENE EXPRESSION PROFILE STATUS AND AMERICAN JOINT COMMISSION ON CANCER STAGE IN UVEAL MELANOMA. Retina, 40(2), 214–224. https://doi.org/10.1097/IAE.0000000000002385
Berry, Duncan E., Amy C. Schefler, Michael I. Seider, Miguel Materin, Sandra Stinnett, Prithvi Mruthyunjaya, and Prithvi Ocular Oncology Study Consortium. “CORRELATION OF GENE EXPRESSION PROFILE STATUS AND AMERICAN JOINT COMMISSION ON CANCER STAGE IN UVEAL MELANOMA.Retina 40, no. 2 (February 2020): 214–24. https://doi.org/10.1097/IAE.0000000000002385.
Berry DE, Schefler AC, Seider MI, Materin M, Stinnett S, Mruthyunjaya P, et al. CORRELATION OF GENE EXPRESSION PROFILE STATUS AND AMERICAN JOINT COMMISSION ON CANCER STAGE IN UVEAL MELANOMA. Retina. 2020 Feb;40(2):214–24.
Berry, Duncan E., et al. “CORRELATION OF GENE EXPRESSION PROFILE STATUS AND AMERICAN JOINT COMMISSION ON CANCER STAGE IN UVEAL MELANOMA.Retina, vol. 40, no. 2, Feb. 2020, pp. 214–24. Pubmed, doi:10.1097/IAE.0000000000002385.
Berry DE, Schefler AC, Seider MI, Materin M, Stinnett S, Mruthyunjaya P, Ocular Oncology Study Consortium. CORRELATION OF GENE EXPRESSION PROFILE STATUS AND AMERICAN JOINT COMMISSION ON CANCER STAGE IN UVEAL MELANOMA. Retina. 2020 Feb;40(2):214–224.

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

February 2020

Volume

40

Issue

2

Start / End Page

214 / 224

Location

United States

Related Subject Headings

  • Young Adult
  • Uveal Neoplasms
  • United States
  • Societies, Medical
  • Retrospective Studies
  • Ophthalmology & Optometry
  • Ophthalmology
  • Neoplasm Staging
  • Middle Aged
  • Melanoma