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Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis.

Publication ,  Journal Article
Zeggini, E; Thomson, W; Alansari, A; Ollier, W; Donn, R; British Paediatric Rheumatology Study Group
Published in: Rheumatology (Oxford)
April 2002

OBJECTIVES: Juvenile idiopathic arthritis (JIA) is a complex polygenic disorder. The encouraging outcome of anti-tumour necrosis factor (TNF) treatment, as well as serological studies, has implicated TNF and its receptors (TNFRI and TNFRII, or TNFRSF1B) in the pathogenesis of JIA. The purpose of this study was to investigate the exon 6 TNFRII single nucleotide polymorphism (SNP) in a well-defined UK cohort of JIA patients, using case-control association analysis. METHODS: A total of 435 patients, spanning seven JIA subgroups, and 261 healthy individuals were screened for the polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: No significant differences were observed between the SNP allelic or genotypic frequencies of patients and controls, or between JIA subgroups. CONCLUSIONS: This TNFRII exon 6 SNP does not seem to be associated with susceptibility to JIA.

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Published In

Rheumatology (Oxford)

DOI

ISSN

1462-0324

Publication Date

April 2002

Volume

41

Issue

4

Start / End Page

462 / 465

Location

England

Related Subject Headings

  • United Kingdom
  • Receptors, Tumor Necrosis Factor, Type II
  • Receptors, Tumor Necrosis Factor
  • Polymorphism, Single Nucleotide
  • Polymorphism, Restriction Fragment Length
  • Polymerase Chain Reaction
  • Humans
  • Genotype
  • Genetic Testing
  • Genetic Predisposition to Disease
 

Citation

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Zeggini, E., Thomson, W., Alansari, A., Ollier, W., Donn, R., & British Paediatric Rheumatology Study Group. (2002). Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis. Rheumatology (Oxford), 41(4), 462–465. https://doi.org/10.1093/rheumatology/41.4.462
Zeggini, E., W. Thomson, A. Alansari, W. Ollier, R. Donn, and British Paediatric Rheumatology Study Group. “Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis.Rheumatology (Oxford) 41, no. 4 (April 2002): 462–65. https://doi.org/10.1093/rheumatology/41.4.462.
Zeggini E, Thomson W, Alansari A, Ollier W, Donn R, British Paediatric Rheumatology Study Group. Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis. Rheumatology (Oxford). 2002 Apr;41(4):462–5.
Zeggini, E., et al. “Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis.Rheumatology (Oxford), vol. 41, no. 4, Apr. 2002, pp. 462–65. Pubmed, doi:10.1093/rheumatology/41.4.462.
Zeggini E, Thomson W, Alansari A, Ollier W, Donn R, British Paediatric Rheumatology Study Group. Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis. Rheumatology (Oxford). 2002 Apr;41(4):462–465.
Journal cover image

Published In

Rheumatology (Oxford)

DOI

ISSN

1462-0324

Publication Date

April 2002

Volume

41

Issue

4

Start / End Page

462 / 465

Location

England

Related Subject Headings

  • United Kingdom
  • Receptors, Tumor Necrosis Factor, Type II
  • Receptors, Tumor Necrosis Factor
  • Polymorphism, Single Nucleotide
  • Polymorphism, Restriction Fragment Length
  • Polymerase Chain Reaction
  • Humans
  • Genotype
  • Genetic Testing
  • Genetic Predisposition to Disease