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Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis.

Publication ,  Journal Article
Donn, RP; Farhan, A; Stevans, A; Ramanan, A; Ollier, WER; Thomson, W; British Paediatric Rheumatology Study Group,
Published in: Rheumatology (Oxford)
August 2002

OBJECTIVE: To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). METHODS: Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. RESULTS: None of the polymorphisms investigated showed any statistically significant associations with JIA. CONCLUSIONS: The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.

Duke Scholars

Published In

Rheumatology (Oxford)

DOI

ISSN

1462-0324

Publication Date

August 2002

Volume

41

Issue

8

Start / End Page

930 / 936

Location

England

Related Subject Headings

  • White People
  • United Kingdom
  • Transcortin
  • Reference Values
  • Receptors, Estrogen
  • Prolactin
  • Polymorphism, Genetic
  • Pituitary-Adrenal System
  • Microsatellite Repeats
  • Male
 

Citation

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Chicago
ICMJE
MLA
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Donn, R. P., Farhan, A., Stevans, A., Ramanan, A., Ollier, W. E. R., Thomson, W., & British Paediatric Rheumatology Study Group, . (2002). Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. Rheumatology (Oxford), 41(8), 930–936. https://doi.org/10.1093/rheumatology/41.8.930
Donn, R. P., A. Farhan, A. Stevans, A. Ramanan, W. E. R. Ollier, W. Thomson, and W. British Paediatric Rheumatology Study Group. “Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis.Rheumatology (Oxford) 41, no. 8 (August 2002): 930–36. https://doi.org/10.1093/rheumatology/41.8.930.
Donn RP, Farhan A, Stevans A, Ramanan A, Ollier WER, Thomson W, et al. Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. Rheumatology (Oxford). 2002 Aug;41(8):930–6.
Donn, R. P., et al. “Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis.Rheumatology (Oxford), vol. 41, no. 8, Aug. 2002, pp. 930–36. Pubmed, doi:10.1093/rheumatology/41.8.930.
Donn RP, Farhan A, Stevans A, Ramanan A, Ollier WER, Thomson W, British Paediatric Rheumatology Study Group. Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. Rheumatology (Oxford). 2002 Aug;41(8):930–936.
Journal cover image

Published In

Rheumatology (Oxford)

DOI

ISSN

1462-0324

Publication Date

August 2002

Volume

41

Issue

8

Start / End Page

930 / 936

Location

England

Related Subject Headings

  • White People
  • United Kingdom
  • Transcortin
  • Reference Values
  • Receptors, Estrogen
  • Prolactin
  • Polymorphism, Genetic
  • Pituitary-Adrenal System
  • Microsatellite Repeats
  • Male