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Lack of association between juvenile idiopathic arthritis and fas gene polymorphism.

Publication ,  Journal Article
Donn, R; Zeggini, E; Shelley, E; Ollier, W; Thomson, W; British Paediatric Rheumatology Study Group,
Published in: J Rheumatol
January 2002

OBJECTIVE: Juvenile idiopathic arthritis (JIA) is a complex genetic disease of autoimmune etiology. Fas is a molecule with a pivotal role in apoptosis and hence in immune regulation. Elevated transcriptional levels of Fas in the synovial fluid of patients with JIA suggest that it might be implicated in disease etiopathogenesis. We investigated whether a polymorphism in the Fas promoter region (-670) confers susceptibility to JIA. METHODS: In this association study, 342 UK patients with JIA and 255 healthy individuals were genotyped for the polymorphism using polymerase chain reaction restriction fragment length polymorphism. Comparisons of the genotypic frequencies were made using chi-square analysis. RESULTS: No statistically significant differences were found when the genotype frequencies of the -670 Fas polymorphism were compared between the JIA cases and the control panel. Similarly, no differences were seen between the JIA subgroups, or when the patients were divided on the basis of rheumatoid factor or antinuclear antibody positivity. CONCLUSION: The -670 polymorphism of Fas does not appear to be associated with susceptibility to JIA.

Duke Scholars

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

January 2002

Volume

29

Issue

1

Start / End Page

166 / 168

Location

Canada

Related Subject Headings

  • fas Receptor
  • Rheumatoid Factor
  • Polymorphism, Genetic
  • Mutation
  • Joints
  • Humans
  • Genotype
  • Genetic Testing
  • Genetic Predisposition to Disease
  • Gene Frequency
 

Citation

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MLA
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Donn, R., Zeggini, E., Shelley, E., Ollier, W., Thomson, W., & British Paediatric Rheumatology Study Group, . (2002). Lack of association between juvenile idiopathic arthritis and fas gene polymorphism. J Rheumatol, 29(1), 166–168.
Donn, Rachelle, Eleftheria Zeggini, Emma Shelley, William Ollier, Wendy Thomson, and Wendy British Paediatric Rheumatology Study Group. “Lack of association between juvenile idiopathic arthritis and fas gene polymorphism.J Rheumatol 29, no. 1 (January 2002): 166–68.
Donn R, Zeggini E, Shelley E, Ollier W, Thomson W, British Paediatric Rheumatology Study Group. Lack of association between juvenile idiopathic arthritis and fas gene polymorphism. J Rheumatol. 2002 Jan;29(1):166–8.
Donn, Rachelle, et al. “Lack of association between juvenile idiopathic arthritis and fas gene polymorphism.J Rheumatol, vol. 29, no. 1, Jan. 2002, pp. 166–68.
Donn R, Zeggini E, Shelley E, Ollier W, Thomson W, British Paediatric Rheumatology Study Group. Lack of association between juvenile idiopathic arthritis and fas gene polymorphism. J Rheumatol. 2002 Jan;29(1):166–168.

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

January 2002

Volume

29

Issue

1

Start / End Page

166 / 168

Location

Canada

Related Subject Headings

  • fas Receptor
  • Rheumatoid Factor
  • Polymorphism, Genetic
  • Mutation
  • Joints
  • Humans
  • Genotype
  • Genetic Testing
  • Genetic Predisposition to Disease
  • Gene Frequency