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Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.

Publication ,  Journal Article
Hinks, A; Ke, X; Barton, A; Eyre, S; Bowes, J; Worthington, J; Thompson, SD; Langefeld, CD; Glass, DN; Thomson, W ...
Published in: Arthritis Rheum
January 2009

OBJECTIVE: IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide polymorphisms (SNPs) within this gene with type 1 diabetes mellitus (DM), Graves' disease, rheumatoid arthritis (RA), and multiple sclerosis (MS). The aim of this study was to determine whether SNPs within the IL2RA/CD25 gene are associated with juvenile idiopathic arthritis (JIA). METHODS: Three SNPs within the IL2RA/CD25 gene, that previously showed evidence of an association with either RA, MS, or type 1 DM, were selected for genotyping in UK JIA cases (n=654) and controls (n=3,849). Data for 1 SNP (rs2104286) were also available from North American JIA cases (n=747) and controls (n=1,161). Association analyses were performed using Plink software. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. RESULTS: SNP rs2104286 within the IL2RA/CD25 gene was significantly associated with UK JIA cases (OR for the allele 0.76 [95% CI 0.66-0.88], P for trend=0.0002). A second SNP (rs41295061) also showed modest evidence for association with JIA (OR 0.80 [95% CI 0.63-1.0], P=0.05). Association with rs2104286 was convincingly replicated in the North American JIA cohort (OR 0.84 [95% CI 0.65-0.99], P for trend=0.05). Meta-analysis of the 2 cohorts yielded highly significant evidence of association with JIA (OR 0.76 [95% CI 0.62-0.88], P=4.9x10(-5)). CONCLUSION: These results provide strong evidence that the IL2RA/CD25 gene represents a JIA susceptibility locus. Further investigation of the gene using both genetic and functional approaches is now required.

Duke Scholars

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

January 2009

Volume

60

Issue

1

Start / End Page

251 / 257

Location

United States

Related Subject Headings

  • United Kingdom
  • Registries
  • Polymorphism, Single Nucleotide
  • North America
  • Interleukin-2 Receptor alpha Subunit
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Gene Frequency
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Hinks, A., Ke, X., Barton, A., Eyre, S., Bowes, J., Worthington, J., … British Society of Paediatric and Adolescent Rheumatology Study Group, . (2009). Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. Arthritis Rheum, 60(1), 251–257. https://doi.org/10.1002/art.24187
Hinks, Anne, Xiayi Ke, Anne Barton, Steve Eyre, John Bowes, Jane Worthington, Susan D. Thompson, et al. “Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.Arthritis Rheum 60, no. 1 (January 2009): 251–57. https://doi.org/10.1002/art.24187.
Hinks A, Ke X, Barton A, Eyre S, Bowes J, Worthington J, et al. Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. Arthritis Rheum. 2009 Jan;60(1):251–7.
Hinks, Anne, et al. “Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.Arthritis Rheum, vol. 60, no. 1, Jan. 2009, pp. 251–57. Pubmed, doi:10.1002/art.24187.
Hinks A, Ke X, Barton A, Eyre S, Bowes J, Worthington J, Thompson SD, Langefeld CD, Glass DN, Thomson W, UK Rheumatoid Arthritis Genetics Consortium, British Society of Paediatric and Adolescent Rheumatology Study Group. Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. Arthritis Rheum. 2009 Jan;60(1):251–257.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

January 2009

Volume

60

Issue

1

Start / End Page

251 / 257

Location

United States

Related Subject Headings

  • United Kingdom
  • Registries
  • Polymorphism, Single Nucleotide
  • North America
  • Interleukin-2 Receptor alpha Subunit
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Gene Frequency
  • Cohort Studies