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Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases.

Publication ,  Journal Article
Sambade, M; Deal, A; Schorzman, A; Luft, JC; Bowerman, C; Chu, K; Karginova, O; Swearingen, AV; Zamboni, W; DeSimone, J; Anders, CK
Published in: Nanomedicine (London, England)
August 2016

Particle Replication in Nonwetting Templates (PRINT(®)) PLGA nanoparticles of docetaxel and acid-labile C2-dimethyl-Si-Docetaxel were evaluated with small molecule docetaxel as treatments for non-small-cell lung cancer brain metastases.Pharmacokinetics, survival, tumor growth and mice weight change were efficacy measures against intracranial A549 tumors in nude mice. Treatments were administered by intravenous injection.Intracranial tumor concentrations of PRINT-docetaxel and PRINT-C2-docetaxel were 13- and sevenfold greater, respectively, than SM-docetaxel. C2-docetaxel conversion to docetaxel was threefold higher in intracranial tumor as compared with nontumor tissues. PRINT-C2-docetaxel increased median survival by 35% with less toxicity as compared with other treatments.The decreased toxicity of the PRINT-C2-docetaxel improved treatment efficacy against non-small-cell lung cancer brain metastasis.

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Published In

Nanomedicine (London, England)

DOI

EISSN

1748-6963

ISSN

1743-5889

Publication Date

August 2016

Volume

11

Issue

15

Start / End Page

1947 / 1955

Related Subject Headings

  • Taxoids
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Particle Size
  • Neoplasm Transplantation
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Mice, Nude
  • Mice
  • Lung Neoplasms
 

Citation

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MLA
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Sambade, M., Deal, A., Schorzman, A., Luft, J. C., Bowerman, C., Chu, K., … Anders, C. K. (2016). Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases. Nanomedicine (London, England), 11(15), 1947–1955. https://doi.org/10.2217/nnm-2016-0147
Sambade, Maria, Allison Deal, Allison Schorzman, J Christopher Luft, Charles Bowerman, Kevin Chu, Olga Karginova, et al. “Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases.Nanomedicine (London, England) 11, no. 15 (August 2016): 1947–55. https://doi.org/10.2217/nnm-2016-0147.
Sambade M, Deal A, Schorzman A, Luft JC, Bowerman C, Chu K, et al. Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases. Nanomedicine (London, England). 2016 Aug;11(15):1947–55.
Sambade, Maria, et al. “Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases.Nanomedicine (London, England), vol. 11, no. 15, Aug. 2016, pp. 1947–55. Epmc, doi:10.2217/nnm-2016-0147.
Sambade M, Deal A, Schorzman A, Luft JC, Bowerman C, Chu K, Karginova O, Swearingen AV, Zamboni W, DeSimone J, Anders CK. Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases. Nanomedicine (London, England). 2016 Aug;11(15):1947–1955.
Journal cover image

Published In

Nanomedicine (London, England)

DOI

EISSN

1748-6963

ISSN

1743-5889

Publication Date

August 2016

Volume

11

Issue

15

Start / End Page

1947 / 1955

Related Subject Headings

  • Taxoids
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Particle Size
  • Neoplasm Transplantation
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Mice, Nude
  • Mice
  • Lung Neoplasms