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Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis.

Publication ,  Journal Article
Meriden, Z; Shi, C; Edil, BH; Ellison, T; Wolfgang, CL; Cornish, TC; Schulick, RD; Hruban, RH
Published in: Am J Surg Pathol
July 2011

Distinguishing between solid-pseudopapillary neoplasms (SPNs) and pancreatic neuroendocrine tumors (PanNETs) may pose a diagnostic dilemma. Both can demonstrate solid growth patterns, and both can be immunoreactive with neuroendocrine markers such as synaptophysin and CD56. One well-established feature of SPNs is the presence of hyaline globules, which in contrast has only rarely been reported in PanNETs. Clinicopathologic features of 361 cases originally classified as PanNETs were examined. Of these, 24 tumors (6.6%) had hyaline globules, raising the possibility of SPN. Immunohistochemistry for β-catenin was performed on these 24 neoplasms, and showed nuclear labeling in 6 cases. These 6 cases, which also demonstrated cytoplasmic CD10 staining, were reclassified as SPNs. The remaining 18 cases maintained their original diagnosis as PanNETs, and the hyaline globules in these cases were periodic acid-Schiff (PAS) positive, diastase resistant, and immunoreactive with α-1-antitrypsin. All 24 cases were histologically re-evaluated, and the pattern of invasion, presence of clear cells, and nuclear grooves were found to be helpful in distinguishing SPNs from PanNETs. We conclude that the presence of hyaline globules should raise SPNs in the differential diagnosis of a solid cellular neoplasm of the pancreas. However, this should not be used as the sole criterion in the diagnosis of SPNs, as hyaline globules may also be seen in 5% of PanNETs. Immunohistochemical and histologic features supporting the diagnosis of SPNs over PanNETs include CD10 and nuclear β-catenin labeling, an insidious pattern of invasion, clear cells, and nuclear grooves.

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Published In

Am J Surg Pathol

DOI

EISSN

1532-0979

Publication Date

July 2011

Volume

35

Issue

7

Start / End Page

981 / 988

Location

United States

Related Subject Headings

  • beta Catenin
  • Periodic Acid-Schiff Reaction
  • Pathology
  • Pancreatic Neoplasms
  • Neprilysin
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Lymph Nodes
  • Hyalin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Meriden, Z., Shi, C., Edil, B. H., Ellison, T., Wolfgang, C. L., Cornish, T. C., … Hruban, R. H. (2011). Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol, 35(7), 981–988. https://doi.org/10.1097/PAS.0b013e31821a9a14
Meriden, Zina, Chanjuan Shi, Barish H. Edil, Trevor Ellison, Christopher L. Wolfgang, Toby C. Cornish, Richard D. Schulick, and Ralph H. Hruban. “Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis.Am J Surg Pathol 35, no. 7 (July 2011): 981–88. https://doi.org/10.1097/PAS.0b013e31821a9a14.
Meriden Z, Shi C, Edil BH, Ellison T, Wolfgang CL, Cornish TC, et al. Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol. 2011 Jul;35(7):981–8.
Meriden, Zina, et al. “Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis.Am J Surg Pathol, vol. 35, no. 7, July 2011, pp. 981–88. Pubmed, doi:10.1097/PAS.0b013e31821a9a14.
Meriden Z, Shi C, Edil BH, Ellison T, Wolfgang CL, Cornish TC, Schulick RD, Hruban RH. Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol. 2011 Jul;35(7):981–988.

Published In

Am J Surg Pathol

DOI

EISSN

1532-0979

Publication Date

July 2011

Volume

35

Issue

7

Start / End Page

981 / 988

Location

United States

Related Subject Headings

  • beta Catenin
  • Periodic Acid-Schiff Reaction
  • Pathology
  • Pancreatic Neoplasms
  • Neprilysin
  • Middle Aged
  • Male
  • Lymphatic Metastasis
  • Lymph Nodes
  • Hyalin