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APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale.

Publication ,  Journal Article
Freedman, BI; Moxey-Mims, MM; Alexander, AA; Astor, BC; Birdwell, KA; Bowden, DW; Bowen, G; Bromberg, J; Craven, TE; Dadhania, DM; Divers, J ...
Published in: Kidney Int Rep
March 2020

INTRODUCTION: Much of the higher risk for end-stage kidney disease (ESKD) in African American individuals relates to ancestry-specific variation in the apolipoprotein L1 gene (APOL1). Relative to kidneys from European American deceased-donors, kidneys from African American deceased-donors have shorter allograft survival and African American living-kidney donors more often develop ESKD. The National Institutes of Health (NIH)-sponsored APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) is prospectively assessing kidney allograft survival from donors with recent African ancestry based on donor and recipient APOL1 genotypes. METHODS: APOLLO will evaluate outcomes from 2614 deceased kidney donor-recipient pairs, as well as additional living-kidney donor-recipient pairs and unpaired deceased-donor kidneys. RESULTS: The United Network for Organ Sharing (UNOS), Association of Organ Procurement Organizations, American Society of Transplantation, American Society for Histocompatibility and Immunogenetics, and nearly all U.S. kidney transplant programs, organ procurement organizations (OPOs), and histocompatibility laboratories are participating in this observational study. APOLLO employs a central institutional review board (cIRB) and maintains voluntary partnerships with OPOs and histocompatibility laboratories. A Community Advisory Council composed of African American individuals with a personal or family history of kidney disease has advised the NIH Project Office and Steering Committee since inception. UNOS is providing data for outcome analyses. CONCLUSION: This article describes unique aspects of the protocol, design, and performance of APOLLO. Results will guide use of APOL1 genotypic data to improve the assessment of quality in deceased-donor kidneys and could increase numbers of transplanted kidneys, reduce rates of discard, and improve the safety of living-kidney donation.

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Published In

Kidney Int Rep

DOI

EISSN

2468-0249

Publication Date

March 2020

Volume

5

Issue

3

Start / End Page

278 / 288

Location

United States

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Freedman, B. I., Moxey-Mims, M. M., Alexander, A. A., Astor, B. C., Birdwell, K. A., Bowden, D. W., … Brennan, D. C. (2020). APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale. Kidney Int Rep, 5(3), 278–288. https://doi.org/10.1016/j.ekir.2019.11.022
Freedman, Barry I., Marva M. Moxey-Mims, Amir A. Alexander, Brad C. Astor, Kelly A. Birdwell, Donald W. Bowden, Gordon Bowen, et al. “APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale.Kidney Int Rep 5, no. 3 (March 2020): 278–88. https://doi.org/10.1016/j.ekir.2019.11.022.
Freedman BI, Moxey-Mims MM, Alexander AA, Astor BC, Birdwell KA, Bowden DW, et al. APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale. Kidney Int Rep. 2020 Mar;5(3):278–88.
Freedman, Barry I., et al. “APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale.Kidney Int Rep, vol. 5, no. 3, Mar. 2020, pp. 278–88. Pubmed, doi:10.1016/j.ekir.2019.11.022.
Freedman BI, Moxey-Mims MM, Alexander AA, Astor BC, Birdwell KA, Bowden DW, Bowen G, Bromberg J, Craven TE, Dadhania DM, Divers J, Doshi MD, Eidbo E, Fornoni A, Gautreaux MD, Gbadegesin RA, Gee PO, Guerra G, Hsu C-Y, Iltis AS, Jefferson N, Julian BA, Klassen DK, Koty PP, Langefeld CD, Lentine KL, Ma L, Mannon RB, Menon MC, Mohan S, Moore JB, Murphy B, Newell KA, Odim J, Ortigosa-Goggins M, Palmer ND, Park M, Parsa A, Pastan SO, Poggio ED, Rajapakse N, Reeves-Daniel AM, Rosas SE, Russell LP, Sawinski D, Smith SC, Spainhour M, Stratta RJ, Weir MR, Reboussin DM, Kimmel PL, Brennan DC. APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): Design and Rationale. Kidney Int Rep. 2020 Mar;5(3):278–288.
Journal cover image

Published In

Kidney Int Rep

DOI

EISSN

2468-0249

Publication Date

March 2020

Volume

5

Issue

3

Start / End Page

278 / 288

Location

United States

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences