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Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications.

Publication ,  Journal Article
Leckey, BD; Selim, MA; Al-Rohil, RN
Published in: Journal of cutaneous pathology
June 2020

SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently recognized entity with undifferentiated rhabdoid morphology and mutations in the switch/sucrose nonfermenting BRG1-associated factors complex. Patients are typically males in their fifth decade with a history of smoking who present with rapidly progressive intrathoracic disease and follow an aggressive clinical course. Metastatic disease is reported in up to 77% of cases; however, to our knowledge, cutaneous metastasis has not been reported nor has it been reported as the initial manifestation of the disease. Recognizing SMARCA4-DTS from other types of epithelioid tumors that involve the skin is clinically relevant, as targeted therapies for SMARC-deficient tumors are currently being investigated and early clinical trial data show therapeutic benefit.

Duke Scholars

Published In

Journal of cutaneous pathology

DOI

EISSN

1600-0560

ISSN

0303-6987

Publication Date

June 2020

Volume

47

Issue

6

Start / End Page

561 / 565

Related Subject Headings

  • Transcription Factors
  • Thoracic Neoplasms
  • Soft Tissue Neoplasms
  • Smoking
  • Skin Neoplasms
  • Sarcoma
  • Nuclear Proteins
  • Mutation
  • Middle Aged
  • Male
 

Citation

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Leckey, B. D., Selim, M. A., & Al-Rohil, R. N. (2020). Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications. Journal of Cutaneous Pathology, 47(6), 561–565. https://doi.org/10.1111/cup.13652
Leckey, Bruce D., M Angelica Selim, and Rami N. Al-Rohil. “Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications.Journal of Cutaneous Pathology 47, no. 6 (June 2020): 561–65. https://doi.org/10.1111/cup.13652.
Leckey BD, Selim MA, Al-Rohil RN. Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications. Journal of cutaneous pathology. 2020 Jun;47(6):561–5.
Leckey, Bruce D., et al. “Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications.Journal of Cutaneous Pathology, vol. 47, no. 6, June 2020, pp. 561–65. Epmc, doi:10.1111/cup.13652.
Leckey BD, Selim MA, Al-Rohil RN. Cutaneous metastasis of SMARCA4-deficient thoracic sarcoma: A diagnostic dilemma with therapeutic implications. Journal of cutaneous pathology. 2020 Jun;47(6):561–565.
Journal cover image

Published In

Journal of cutaneous pathology

DOI

EISSN

1600-0560

ISSN

0303-6987

Publication Date

June 2020

Volume

47

Issue

6

Start / End Page

561 / 565

Related Subject Headings

  • Transcription Factors
  • Thoracic Neoplasms
  • Soft Tissue Neoplasms
  • Smoking
  • Skin Neoplasms
  • Sarcoma
  • Nuclear Proteins
  • Mutation
  • Middle Aged
  • Male