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Amino Acid-Based Poly(ester urea)s as a Matrix for Extended Release of Entecavir.

Publication ,  Journal Article
Abel, AK; Dreger, NZ; Nettleton, K; Gustafson, TP; Forster, SP; Becker, ML
Published in: Biomacromolecules
February 2020

The use of polymers as excipients for drug delivery has afforded stable formulations that reliably control the release of active pharmaceutical ingredients (APIs). While many materials are available and used, few polymers exhibit the numerous advantages, including amorphous characteristics, noninflammatory properties, and resorbable degradation products, like those of poly(ester urea)s (PEUs). Furthermore, stability issues that arise in various APIs can make formulation optimization difficult. Herein, a series of PEUs were synthesized that vary by the fraction of l-phenylalanine monomer incorporated into the copolymerization. The various PEUs and entecavir monohydrate were dry-mixed at different weight percentages (15, 30, and 50%). Filaments of the PEU formulations were extruded and analyzed quantitatively for drug loading and content uniformity by using μ-CT and UPLC analysis. Drug dissolution profiles from filament segments were monitored over a 4-week period and ultimately showed that the controlled release of entecavir was influenced by the incorporation of the l-phenylalanine within the polymer.

Duke Scholars

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

February 2020

Volume

21

Issue

2

Start / End Page

946 / 954

Related Subject Headings

  • X-Ray Microtomography
  • Urea
  • Polymers
  • Polyesters
  • Guanine
  • Delayed-Action Preparations
  • Antiviral Agents
  • Amino Acids
  • 40 Engineering
  • 34 Chemical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Abel, A. K., Dreger, N. Z., Nettleton, K., Gustafson, T. P., Forster, S. P., & Becker, M. L. (2020). Amino Acid-Based Poly(ester urea)s as a Matrix for Extended Release of Entecavir. Biomacromolecules, 21(2), 946–954. https://doi.org/10.1021/acs.biomac.9b01586
Abel, Alexandra K., Nathan Z. Dreger, Karissa Nettleton, Tiffany P. Gustafson, Seth P. Forster, and Matthew L. Becker. “Amino Acid-Based Poly(ester urea)s as a Matrix for Extended Release of Entecavir.Biomacromolecules 21, no. 2 (February 2020): 946–54. https://doi.org/10.1021/acs.biomac.9b01586.
Abel AK, Dreger NZ, Nettleton K, Gustafson TP, Forster SP, Becker ML. Amino Acid-Based Poly(ester urea)s as a Matrix for Extended Release of Entecavir. Biomacromolecules. 2020 Feb;21(2):946–54.
Abel, Alexandra K., et al. “Amino Acid-Based Poly(ester urea)s as a Matrix for Extended Release of Entecavir.Biomacromolecules, vol. 21, no. 2, Feb. 2020, pp. 946–54. Epmc, doi:10.1021/acs.biomac.9b01586.
Abel AK, Dreger NZ, Nettleton K, Gustafson TP, Forster SP, Becker ML. Amino Acid-Based Poly(ester urea)s as a Matrix for Extended Release of Entecavir. Biomacromolecules. 2020 Feb;21(2):946–954.
Journal cover image

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

February 2020

Volume

21

Issue

2

Start / End Page

946 / 954

Related Subject Headings

  • X-Ray Microtomography
  • Urea
  • Polymers
  • Polyesters
  • Guanine
  • Delayed-Action Preparations
  • Antiviral Agents
  • Amino Acids
  • 40 Engineering
  • 34 Chemical sciences