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Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus.

Publication ,  Journal Article
Levine, AT; Born, HA; Landstrom, AP; Larson, S; Lee, WL; Dao, AT; Wehrens, XH; Lai, Y-C; Anderson, AE
Published in: Sci Rep
March 4, 2020

Status epilepticus (SE) is a prevalent disorder associated with significant morbidity, including the development of epilepsy and mortality. Cardiac arrhythmias (i.e. inappropriate sinus tachycardia and bradycardia, asystole, and atrioventricular blocks) are observed in patients following SE. We characterized ictal (during a seizure) and interictal (between seizure) cardiac arrhythmogenesis following SE using continuous electrocardiography and video electroencephalography (vEEG) recordings throughout a 14-day monitoring period in an intrahippocampal chemoconvulsant mouse model that develops epilepsy. We quantified heart rhythm abnormalities and examined whether the frequency of cardiac events correlated with epileptiform activity, circadian (light/dark) cycle, the presence of seizures, and survival during this period of early epileptogenesis (the development of epilepsy) following SE. Shortly following SE, mice developed an increased interictal heart rate and heart rhythm abnormalities (i.e. sinus pause and sinus arrhythmias) when compared to control mice. Heart rhythm abnormalities were more frequent during the light cycle and were not correlated with increased epileptiform activity or seizure frequency. Finally, SE animals had early mortality, and a death event captured during vEEG recording demonstrated severe bradycardia prior to death. These cardiac changes occurred within 14 days after SE and may represent an early risk factor for sudden death following SE.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

March 4, 2020

Volume

10

Issue

1

Start / End Page

4043

Location

England

Related Subject Headings

  • Status Epilepticus
  • Mice
  • Male
  • Kainic Acid
  • Electroencephalography
  • Disease Models, Animal
  • Circadian Rhythm
  • Arrhythmias, Cardiac
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
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Levine, A. T., Born, H. A., Landstrom, A. P., Larson, S., Lee, W. L., Dao, A. T., … Anderson, A. E. (2020). Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus. Sci Rep, 10(1), 4043. https://doi.org/10.1038/s41598-020-60324-8
Levine, Amber T., Heather A. Born, Andrew P. Landstrom, Samuel Larson, Wai Ling Lee, An T. Dao, Xander H. Wehrens, Yi-Chen Lai, and Anne E. Anderson. “Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus.Sci Rep 10, no. 1 (March 4, 2020): 4043. https://doi.org/10.1038/s41598-020-60324-8.
Levine AT, Born HA, Landstrom AP, Larson S, Lee WL, Dao AT, et al. Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus. Sci Rep. 2020 Mar 4;10(1):4043.
Levine, Amber T., et al. “Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus.Sci Rep, vol. 10, no. 1, Mar. 2020, p. 4043. Pubmed, doi:10.1038/s41598-020-60324-8.
Levine AT, Born HA, Landstrom AP, Larson S, Lee WL, Dao AT, Wehrens XH, Lai Y-C, Anderson AE. Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus. Sci Rep. 2020 Mar 4;10(1):4043.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

March 4, 2020

Volume

10

Issue

1

Start / End Page

4043

Location

England

Related Subject Headings

  • Status Epilepticus
  • Mice
  • Male
  • Kainic Acid
  • Electroencephalography
  • Disease Models, Animal
  • Circadian Rhythm
  • Arrhythmias, Cardiac
  • Animals