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The Longitudinal Parallel Process Analysis of Biomarkers of Oxidative Stress, Symptom Clusters, and Cognitive Function in Children With Leukemia.

Publication ,  Journal Article
Hooke, MC; Hatch, D; Hockenberry, MJ; Whitman, S; Moore, I; Montgomery, D; Marano, K; Mitby, P; Scheurer, ME; Taylor, O; Pan, W
Published in: Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
July 2020

Background: During treatment for acute lymphoblastic leukemia (ALL), children report co-occurring symptoms of fatigue, sleep disturbance, pain, nausea, and depression as a symptom cluster. Central nervous system-directed ALL therapies also put children at risk for cognitive impairments. Cancer therapies can cause an increase in oxidative stress, which may contribute to treatment-related symptoms. This study examined the longitudinal relationships between biomarkers of oxidative stress in the cerebrospinal fluid, the Childhood Cancer Symptom Cluster-Leukemia (CCSC-L), and cognition, in children over the first year of ALL treatment. Methods: Glutathione (GSH) biomarkers of oxidative stress were measured in cerebrospinal fluid collected during treatment lumbar punctures. GSH biomarkers, symptoms, and cognitive function of 132 children aged 3 to 18 years were evaluated at four time points during the first year of leukemia treatment. Participants, 7 years and older, completed self-report measures, and parents reported for younger children. Cognitive function measurements for all participants were completed by parents. A longitudinal parallel-process model was used to explore the influence of the initial measurement and the subsequent change over four time points of the GSH biomarkers on the CCSC-L and cognition. Results: GSH biomarkers increased over the four time points indicating decreasing oxidative stress. When GSH biomarkers were higher (less oxidative stress) at the initial measurement, the CCSC-L severity was lower, cognition was better, and cognition improved over the four measurements. Screening children for high levels of oxidative stress would be a foundation for future intervention studies to address symptom distress and cognitive impairments.

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Published In

Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses

DOI

EISSN

1532-8457

ISSN

1043-4542

Publication Date

July 2020

Volume

37

Issue

4

Start / End Page

244 / 254

Related Subject Headings

  • Syndrome
  • Sleep Wake Disorders
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Pain
  • Oxidative Stress
  • Oncology Nursing
  • Nursing
  • Nausea
  • Male
  • Longitudinal Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hooke, M. C., Hatch, D., Hockenberry, M. J., Whitman, S., Moore, I., Montgomery, D., … Pan, W. (2020). The Longitudinal Parallel Process Analysis of Biomarkers of Oxidative Stress, Symptom Clusters, and Cognitive Function in Children With Leukemia. Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses, 37(4), 244–254. https://doi.org/10.1177/1043454220909785
Hooke, Mary C., Daniel Hatch, Marilyn J. Hockenberry, Susan Whitman, Ida Moore, David Montgomery, Kari Marano, et al. “The Longitudinal Parallel Process Analysis of Biomarkers of Oxidative Stress, Symptom Clusters, and Cognitive Function in Children With Leukemia.Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses 37, no. 4 (July 2020): 244–54. https://doi.org/10.1177/1043454220909785.
Hooke MC, Hatch D, Hockenberry MJ, Whitman S, Moore I, Montgomery D, et al. The Longitudinal Parallel Process Analysis of Biomarkers of Oxidative Stress, Symptom Clusters, and Cognitive Function in Children With Leukemia. Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses. 2020 Jul;37(4):244–54.
Hooke, Mary C., et al. “The Longitudinal Parallel Process Analysis of Biomarkers of Oxidative Stress, Symptom Clusters, and Cognitive Function in Children With Leukemia.Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses, vol. 37, no. 4, July 2020, pp. 244–54. Epmc, doi:10.1177/1043454220909785.
Hooke MC, Hatch D, Hockenberry MJ, Whitman S, Moore I, Montgomery D, Marano K, Mitby P, Scheurer ME, Taylor O, Pan W. The Longitudinal Parallel Process Analysis of Biomarkers of Oxidative Stress, Symptom Clusters, and Cognitive Function in Children With Leukemia. Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses. 2020 Jul;37(4):244–254.
Journal cover image

Published In

Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses

DOI

EISSN

1532-8457

ISSN

1043-4542

Publication Date

July 2020

Volume

37

Issue

4

Start / End Page

244 / 254

Related Subject Headings

  • Syndrome
  • Sleep Wake Disorders
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Pain
  • Oxidative Stress
  • Oncology Nursing
  • Nursing
  • Nausea
  • Male
  • Longitudinal Studies