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Association Between Early Cognitive Impairment and Midterm Functional Outcomes Among Chinese Acute Ischemic Stroke Patients: A Longitudinal Study.

Publication ,  Journal Article
Li, J; Wang, J; Wu, B; Xu, H; Wu, X; Zhou, L; Deng, B
Published in: Frontiers in neurology
January 2020

Background: Cognitive decline is common after stroke. The influence of early cognitive impairment on midterm functional outcomes among Chinese acute ischemic stroke (AIS) patients has not been fully studied. The aim of the study was to assess the association between early cognitive impairment and midterm functional outcomes among Chinese AIS patients. Methods: A longitudinal survey focusing on Chinese AIS patients was conducted in three stroke centers in Shanghai, China (July to December 2016). A total of 185 eligible patients were interviewed at acute stage and at 1, 3, and 6 months after onset. Patients' functional outcomes were measured by modified Rankin Scale (mRS) and Barthel Index (BI) at each time point. Cognitive function was assessed using Montreal Cognitive Assessment, Changsha version (MoCA-CS), within 7 days after stroke onset. Covariates included patient's demographic characteristics, socioeconomic status, clinical characteristics of stroke, vascular risk factors, receiving rehabilitation after discharge from acute hospital, and recurrence. Generalized linear mixed models and general linear mixed models were applied. Results: The prevalence of cognitive impairment at acute stage of stroke among these patients was 88.1%. The risk of disability (mRS 2-5) of all patients after stroke decreased over time (OR = 0.491, 95% CI = 0.401-0.603). The risk of disability among those with cognitive impairment increased compared with those with normal cognition (OR = 7.384, 95% CI = 1.041-52.407). The BI score of all patients increased over time after controlling for covariates (β = 1.51, p < 0.01). The BI score of those with cognitive impairment was lower than that with normal cognition over the follow-up period after controlling for other covariates (β = -8.11, p < 0.05). Conclusions: This study showed that early cognitive impairment was associated with higher risk of disability and poor activity of daily living (ADL) among Chinese AIS patients. Further studies are needed to examine the linkage between multi-domain cognitive impairment and long-term disability and ADL among stroke survivors by using neuropsychological test batteries.

Duke Scholars

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Published In

Frontiers in neurology

DOI

EISSN

1664-2295

ISSN

1664-2295

Publication Date

January 2020

Volume

11

Start / End Page

20

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1701 Psychology
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
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MLA
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Li, J., Wang, J., Wu, B., Xu, H., Wu, X., Zhou, L., & Deng, B. (2020). Association Between Early Cognitive Impairment and Midterm Functional Outcomes Among Chinese Acute Ischemic Stroke Patients: A Longitudinal Study. Frontiers in Neurology, 11, 20. https://doi.org/10.3389/fneur.2020.00020
Li, Juan, Jing Wang, Bei Wu, Hanzhang Xu, Xiongfeng Wu, Lanshu Zhou, and Benqiang Deng. “Association Between Early Cognitive Impairment and Midterm Functional Outcomes Among Chinese Acute Ischemic Stroke Patients: A Longitudinal Study.Frontiers in Neurology 11 (January 2020): 20. https://doi.org/10.3389/fneur.2020.00020.
Li, Juan, et al. “Association Between Early Cognitive Impairment and Midterm Functional Outcomes Among Chinese Acute Ischemic Stroke Patients: A Longitudinal Study.Frontiers in Neurology, vol. 11, Jan. 2020, p. 20. Epmc, doi:10.3389/fneur.2020.00020.

Published In

Frontiers in neurology

DOI

EISSN

1664-2295

ISSN

1664-2295

Publication Date

January 2020

Volume

11

Start / End Page

20

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1701 Psychology
  • 1109 Neurosciences
  • 1103 Clinical Sciences