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Brachytherapy in Neovascular AMD

Publication ,  Journal Article
Grewal, DS; Vajzovic, L
Published in: Current Ophthalmology Reports
March 1, 2015

Neovascular age-related macular degeneration (AMD) has a complex pathophysiology, and although anti-VEGF therapy has been one of the most significant and successful advances, it is not effective for all patients with neovascular AMD. The potential role of radiation in the management of neovascular AMD has been suggested for several years. While previous work focused on the role of radiation alone, recent trials have evaluated the role of ionizing radiation as a synergistic treatment with anti-VEGF drugs, with endpoints being to reduce choroidal neovascular lesions faster, preserve visual acuity, and extend the treatment interval between injections. We review the current evidence available for the safety and efficacy of radiation in conjunction with anti-VEGF treatment for neovascular AMD delivered using three approaches—epimacular brachytherapy involving a pars plana vitrectomy (Vidion Neovista, Inc., Newark, CA, USA), episcleral brachytherapy without a pars plana vitrectomy (Salutaris Medical Devices, Tucson, AZ), and low-voltage stereotactic radiotherapy (IRay, Oraya Therapeutics, Inc., Newark, CA, USA).

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Published In

Current Ophthalmology Reports

DOI

EISSN

2167-4868

Publication Date

March 1, 2015

Volume

3

Issue

1

Start / End Page

40 / 50
 

Citation

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Chicago
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Grewal, D. S., & Vajzovic, L. (2015). Brachytherapy in Neovascular AMD. Current Ophthalmology Reports, 3(1), 40–50. https://doi.org/10.1007/s40135-014-0061-5
Grewal, D. S., and L. Vajzovic. “Brachytherapy in Neovascular AMD.” Current Ophthalmology Reports 3, no. 1 (March 1, 2015): 40–50. https://doi.org/10.1007/s40135-014-0061-5.
Grewal DS, Vajzovic L. Brachytherapy in Neovascular AMD. Current Ophthalmology Reports. 2015 Mar 1;3(1):40–50.
Grewal, D. S., and L. Vajzovic. “Brachytherapy in Neovascular AMD.” Current Ophthalmology Reports, vol. 3, no. 1, Mar. 2015, pp. 40–50. Scopus, doi:10.1007/s40135-014-0061-5.
Grewal DS, Vajzovic L. Brachytherapy in Neovascular AMD. Current Ophthalmology Reports. 2015 Mar 1;3(1):40–50.
Journal cover image

Published In

Current Ophthalmology Reports

DOI

EISSN

2167-4868

Publication Date

March 1, 2015

Volume

3

Issue

1

Start / End Page

40 / 50