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Curing HIV: Seeking to Target and Clear Persistent Infection.

Publication ,  Journal Article
Margolis, DM; Archin, NM; Cohen, MS; Eron, JJ; Ferrari, G; Garcia, JV; Gay, CL; Goonetilleke, N; Joseph, SB; Swanstrom, R; Turner, A-MW; Wahl, A
Published in: Cell
April 2, 2020

Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of antiretroviral therapy (ART). To remove the stigma and burden of chronic infection, approaches to eradicate or cure HIV infection are desired. Attempts to augment ART with therapies that reverse viral latency, paired with immunotherapies to clear infection, have advanced into the clinic, but the field is still in its infancy. We review foundational studies and highlight new insights in HIV cure research. Together with advances in ART delivery and HIV prevention strategies, future therapies that clear HIV infection may relieve society of the affliction of the HIV pandemic.

Duke Scholars

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

April 2, 2020

Volume

181

Issue

1

Start / End Page

189 / 206

Location

United States

Related Subject Headings

  • Virus Latency
  • Immunotherapy
  • Humans
  • Haplorhini
  • HIV-1
  • HIV Infections
  • Developmental Biology
  • Chronic Disease
  • Anti-HIV Agents
  • Animals
 

Citation

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Chicago
ICMJE
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Margolis, D. M., Archin, N. M., Cohen, M. S., Eron, J. J., Ferrari, G., Garcia, J. V., … Wahl, A. (2020). Curing HIV: Seeking to Target and Clear Persistent Infection. Cell, 181(1), 189–206. https://doi.org/10.1016/j.cell.2020.03.005
Margolis, David M., Nancie M. Archin, Myron S. Cohen, Joseph J. Eron, Guido Ferrari, J Victor Garcia, Cynthia L. Gay, et al. “Curing HIV: Seeking to Target and Clear Persistent Infection.Cell 181, no. 1 (April 2, 2020): 189–206. https://doi.org/10.1016/j.cell.2020.03.005.
Margolis DM, Archin NM, Cohen MS, Eron JJ, Ferrari G, Garcia JV, et al. Curing HIV: Seeking to Target and Clear Persistent Infection. Cell. 2020 Apr 2;181(1):189–206.
Margolis, David M., et al. “Curing HIV: Seeking to Target and Clear Persistent Infection.Cell, vol. 181, no. 1, Apr. 2020, pp. 189–206. Pubmed, doi:10.1016/j.cell.2020.03.005.
Margolis DM, Archin NM, Cohen MS, Eron JJ, Ferrari G, Garcia JV, Gay CL, Goonetilleke N, Joseph SB, Swanstrom R, Turner A-MW, Wahl A. Curing HIV: Seeking to Target and Clear Persistent Infection. Cell. 2020 Apr 2;181(1):189–206.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

April 2, 2020

Volume

181

Issue

1

Start / End Page

189 / 206

Location

United States

Related Subject Headings

  • Virus Latency
  • Immunotherapy
  • Humans
  • Haplorhini
  • HIV-1
  • HIV Infections
  • Developmental Biology
  • Chronic Disease
  • Anti-HIV Agents
  • Animals