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Designing a Rational Follow-Up Schedule for Patients with Extremity Soft Tissue Sarcoma.

Publication ,  Journal Article
Wilson, DAJ; Gazendam, A; Visgauss, J; Perrin, D; Griffin, AM; Chung, PW; Catton, CN; Shultz, D; Ferguson, PC; Wunder, JS
Published in: Ann Surg Oncol
June 2020

PURPOSE: The risk of tumor recurrence after resection of soft tissue sarcoma (STS) necessitates surveillance in follow-up. The objective of this study was to determine the frequency/timing of metastasis and local recurrence following treatment for soft tissue sarcoma, and to use these data to justify an evidence-based follow-up schedule. METHODS: Utilizing a prospective database, a retrospective single center review was performed of all patients with minimum 2-year follow-up after resection of a localized extremity STS. Kaplan-Meier estimates were used to calculate the incidence of local recurrence and metastases on an annual basis for 10 years. RESULTS: We identified a total of 230 low-grade, 626 intermediate-grade and 940 high-grade extremity STS and a total of 721 events, 150 local recurrences and 571 metastases. Based on tumor size and grade, follow-up cohorts were developed that had similar metastatic risk. Using pre-determined thresholds for metastatic event, a follow-up schedule was established for each cohort. CONCLUSION: Based on our results we recommend that patients with small low-grade tumors undergo annual follow-up for 5 years following definitive local treatment. Patients with large low-grade tumors, small intermediate-grade and small high-grade tumors should have follow-up every 6 months for the first 2 years, then yearly to 10 years. Only patients with large intermediate- or high-grade tumors require follow-up every 3 months for the first 2 years, then every 6 months for years 3-5, followed by annually until 10 years.

Duke Scholars

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

June 2020

Volume

27

Issue

6

Start / End Page

2033 / 2041

Location

United States

Related Subject Headings

  • Time Factors
  • Sarcoma
  • Retrospective Studies
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Neoplasm Metastasis
  • Neoplasm Grading
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Wilson, D. A. J., Gazendam, A., Visgauss, J., Perrin, D., Griffin, A. M., Chung, P. W., … Wunder, J. S. (2020). Designing a Rational Follow-Up Schedule for Patients with Extremity Soft Tissue Sarcoma. Ann Surg Oncol, 27(6), 2033–2041. https://doi.org/10.1245/s10434-020-08240-z
Wilson, David A. J., Aaron Gazendam, Julia Visgauss, David Perrin, Anthony M. Griffin, Peter W. Chung, Charles N. Catton, David Shultz, Peter C. Ferguson, and Jay S. Wunder. “Designing a Rational Follow-Up Schedule for Patients with Extremity Soft Tissue Sarcoma.Ann Surg Oncol 27, no. 6 (June 2020): 2033–41. https://doi.org/10.1245/s10434-020-08240-z.
Wilson DAJ, Gazendam A, Visgauss J, Perrin D, Griffin AM, Chung PW, et al. Designing a Rational Follow-Up Schedule for Patients with Extremity Soft Tissue Sarcoma. Ann Surg Oncol. 2020 Jun;27(6):2033–41.
Wilson, David A. J., et al. “Designing a Rational Follow-Up Schedule for Patients with Extremity Soft Tissue Sarcoma.Ann Surg Oncol, vol. 27, no. 6, June 2020, pp. 2033–41. Pubmed, doi:10.1245/s10434-020-08240-z.
Wilson DAJ, Gazendam A, Visgauss J, Perrin D, Griffin AM, Chung PW, Catton CN, Shultz D, Ferguson PC, Wunder JS. Designing a Rational Follow-Up Schedule for Patients with Extremity Soft Tissue Sarcoma. Ann Surg Oncol. 2020 Jun;27(6):2033–2041.
Journal cover image

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

June 2020

Volume

27

Issue

6

Start / End Page

2033 / 2041

Location

United States

Related Subject Headings

  • Time Factors
  • Sarcoma
  • Retrospective Studies
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Neoplasm Metastasis
  • Neoplasm Grading
  • Middle Aged
  • Male