Photo-released drugs: A targeted treatment approach for arthritis
Publication
, Conference
Wickenheisser, V; Zywot, EM; Rabjohns, E; Orlova, N; Marvin, CM; Ding, S; Lawrence, DS; Tarrant, TR
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
January 1, 2020
We have developed a technology that facilitates the targeted delivery of glucocorticoids to arthritic joints thereby side-stepping systemic immune suppression while potentially improving efficacy. Our technology loads phototherapeutics inside of red blood cell (RBC) carriers. This ensures that the inactive, RBC-contained phototherapeutic drug is transported throughout the body and released from the RBC carrier only after triggered release by long-wavelength light. We have demonstrated that medications bound to vitamin B12 can be photo-released from RBCs using tissue penetrating, longwavelength red, far-red, and near infrared light in the collagen antibody-induced arthritis model.
Duke Scholars
Published In
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
DOI
ISSN
1605-7422
Publication Date
January 1, 2020
Volume
11223
Citation
APA
Chicago
ICMJE
MLA
NLM
Wickenheisser, V., Zywot, E. M., Rabjohns, E., Orlova, N., Marvin, C. M., Ding, S., … Tarrant, T. R. (2020). Photo-released drugs: A targeted treatment approach for arthritis. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 11223). https://doi.org/10.1117/12.2546949
Wickenheisser, V., E. M. Zywot, E. Rabjohns, N. Orlova, C. M. Marvin, S. Ding, D. S. Lawrence, and T. R. Tarrant. “Photo-released drugs: A targeted treatment approach for arthritis.” In Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 11223, 2020. https://doi.org/10.1117/12.2546949.
Wickenheisser V, Zywot EM, Rabjohns E, Orlova N, Marvin CM, Ding S, et al. Photo-released drugs: A targeted treatment approach for arthritis. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2020.
Wickenheisser, V., et al. “Photo-released drugs: A targeted treatment approach for arthritis.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11223, 2020. Scopus, doi:10.1117/12.2546949.
Wickenheisser V, Zywot EM, Rabjohns E, Orlova N, Marvin CM, Ding S, Lawrence DS, Tarrant TR. Photo-released drugs: A targeted treatment approach for arthritis. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2020.
Published In
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
DOI
ISSN
1605-7422
Publication Date
January 1, 2020
Volume
11223