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Guidelines and definitions for research on epithelial-mesenchymal transition.

Publication ,  Journal Article
Yang, J; Antin, P; Berx, G; Blanpain, C; Brabletz, T; Bronner, M; Campbell, K; Cano, A; Casanova, J; Christofori, G; Dedhar, S; Derynck, R ...
Published in: Nature reviews. Molecular cell biology
June 2020

Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.

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Published In

Nature reviews. Molecular cell biology

DOI

EISSN

1471-0080

ISSN

1471-0072

Publication Date

June 2020

Volume

21

Issue

6

Start / End Page

341 / 352

Related Subject Headings

  • Terminology as Topic
  • Neoplasms
  • Humans
  • Epithelial-Mesenchymal Transition
  • Developmental Biology
  • Developmental Biology
  • Consensus
  • Cell Plasticity
  • Cell Movement
  • Biomedical Research
 

Citation

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Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., … EMT International Association (TEMTIA). (2020). Guidelines and definitions for research on epithelial-mesenchymal transition. Nature Reviews. Molecular Cell Biology, 21(6), 341–352. https://doi.org/10.1038/s41580-020-0237-9
Yang, Jing, Parker Antin, Geert Berx, Cédric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, et al. “Guidelines and definitions for research on epithelial-mesenchymal transition.Nature Reviews. Molecular Cell Biology 21, no. 6 (June 2020): 341–52. https://doi.org/10.1038/s41580-020-0237-9.
Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, et al. Guidelines and definitions for research on epithelial-mesenchymal transition. Nature reviews Molecular cell biology. 2020 Jun;21(6):341–52.
Yang, Jing, et al. “Guidelines and definitions for research on epithelial-mesenchymal transition.Nature Reviews. Molecular Cell Biology, vol. 21, no. 6, June 2020, pp. 341–52. Epmc, doi:10.1038/s41580-020-0237-9.
Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis A-K, Huang RYJ, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massagué J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G, EMT International Association (TEMTIA). Guidelines and definitions for research on epithelial-mesenchymal transition. Nature reviews Molecular cell biology. 2020 Jun;21(6):341–352.

Published In

Nature reviews. Molecular cell biology

DOI

EISSN

1471-0080

ISSN

1471-0072

Publication Date

June 2020

Volume

21

Issue

6

Start / End Page

341 / 352

Related Subject Headings

  • Terminology as Topic
  • Neoplasms
  • Humans
  • Epithelial-Mesenchymal Transition
  • Developmental Biology
  • Developmental Biology
  • Consensus
  • Cell Plasticity
  • Cell Movement
  • Biomedical Research