Skip to main content
Journal cover image

An Australian experience with temozolomide for the treatment of recurrent high grade gliomas.

Publication ,  Journal Article
Harris, MT; Rosenthal, MA; Ashley, DL; Cher, L
Published in: J Clin Neurosci
July 2001

Temozolomide has an evolving role in the treatment of high grade gliomas. Recent studies suggest that temozolomide is well tolerated and efficacious. This study retrospectively analysed the activity and toxicity associated with temozolomide at two Australian centres over a 24 month period. Fifty-six patients with recurrent high grade gliomas were treated with temozolomide. Patients received temozolomide orally at 150-200mg/m(2)daily, days 1-5, every 4 weeks. The median number of treatment cycles was 4 (1-12). Of the 56 patients, 15 (27%) achieved complete or partial response and 18 (32%) achieved minor response or stable disease. There were no episodes of febrile neutropenia and temozolomide was generally well tolerated. In conclusion, temozolomide is an active therapy in patients with recurrent high grade glioma and our results concord with published studies.

Duke Scholars

Published In

J Clin Neurosci

DOI

ISSN

0967-5868

Publication Date

July 2001

Volume

8

Issue

4

Start / End Page

325 / 327

Location

Scotland

Related Subject Headings

  • Treatment Outcome
  • Temozolomide
  • Retrospective Studies
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Glioma
  • Female
  • Disease-Free Survival
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Harris, M. T., Rosenthal, M. A., Ashley, D. L., & Cher, L. (2001). An Australian experience with temozolomide for the treatment of recurrent high grade gliomas. J Clin Neurosci, 8(4), 325–327. https://doi.org/10.1054/jocn.2000.0809
Harris, M. T., M. A. Rosenthal, D. L. Ashley, and L. Cher. “An Australian experience with temozolomide for the treatment of recurrent high grade gliomas.J Clin Neurosci 8, no. 4 (July 2001): 325–27. https://doi.org/10.1054/jocn.2000.0809.
Harris MT, Rosenthal MA, Ashley DL, Cher L. An Australian experience with temozolomide for the treatment of recurrent high grade gliomas. J Clin Neurosci. 2001 Jul;8(4):325–7.
Harris, M. T., et al. “An Australian experience with temozolomide for the treatment of recurrent high grade gliomas.J Clin Neurosci, vol. 8, no. 4, July 2001, pp. 325–27. Pubmed, doi:10.1054/jocn.2000.0809.
Harris MT, Rosenthal MA, Ashley DL, Cher L. An Australian experience with temozolomide for the treatment of recurrent high grade gliomas. J Clin Neurosci. 2001 Jul;8(4):325–327.
Journal cover image

Published In

J Clin Neurosci

DOI

ISSN

0967-5868

Publication Date

July 2001

Volume

8

Issue

4

Start / End Page

325 / 327

Location

Scotland

Related Subject Headings

  • Treatment Outcome
  • Temozolomide
  • Retrospective Studies
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Glioma
  • Female
  • Disease-Free Survival