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Elastin-Like Polypeptides for Biomedical Applications.

Publication ,  Journal Article
Varanko, AK; Su, JC; Chilkoti, A
Published in: Annual review of biomedical engineering
June 2020

Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties-including lower critical solution temperature phase behavior and minimal immunogenicity-make them attractive materials for a variety of biomedical applications. ELPs also benefit from recombinant synthesis and genetically encoded design; these enable control over the molecular weight and precise incorporation of peptides and pharmacological agents into the sequence. Because their size and sequence are defined, ELPs benefit from exquisite control over their structure and function, qualities that cannot be matched by synthetic polymers. As such, ELPs have been engineered to assemble into unique architectures and display bioactive agents for a variety of applications. This review discusses the design and representative biomedical applications of ELPs, focusing primarily on their use in tissue engineering and drug delivery.

Duke Scholars

Published In

Annual review of biomedical engineering

DOI

EISSN

1545-4274

ISSN

1523-9829

Publication Date

June 2020

Volume

22

Start / End Page

343 / 369

Related Subject Headings

  • Tissue Engineering
  • Temperature
  • Silk
  • Protein Engineering
  • Polymers
  • Peptides
  • Neoplasms
  • Molecular Weight
  • Hydrogels
  • Humans
 

Citation

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ICMJE
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Varanko, A. K., Su, J. C., & Chilkoti, A. (2020). Elastin-Like Polypeptides for Biomedical Applications. Annual Review of Biomedical Engineering, 22, 343–369. https://doi.org/10.1146/annurev-bioeng-092419-061127
Varanko, Anastasia K., Jonathan C. Su, and Ashutosh Chilkoti. “Elastin-Like Polypeptides for Biomedical Applications.Annual Review of Biomedical Engineering 22 (June 2020): 343–69. https://doi.org/10.1146/annurev-bioeng-092419-061127.
Varanko AK, Su JC, Chilkoti A. Elastin-Like Polypeptides for Biomedical Applications. Annual review of biomedical engineering. 2020 Jun;22:343–69.
Varanko, Anastasia K., et al. “Elastin-Like Polypeptides for Biomedical Applications.Annual Review of Biomedical Engineering, vol. 22, June 2020, pp. 343–69. Epmc, doi:10.1146/annurev-bioeng-092419-061127.
Varanko AK, Su JC, Chilkoti A. Elastin-Like Polypeptides for Biomedical Applications. Annual review of biomedical engineering. 2020 Jun;22:343–369.

Published In

Annual review of biomedical engineering

DOI

EISSN

1545-4274

ISSN

1523-9829

Publication Date

June 2020

Volume

22

Start / End Page

343 / 369

Related Subject Headings

  • Tissue Engineering
  • Temperature
  • Silk
  • Protein Engineering
  • Polymers
  • Peptides
  • Neoplasms
  • Molecular Weight
  • Hydrogels
  • Humans