Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma.
Publication
, Journal Article
Boot, A; Jiang, N; Rozen, SG
Published in: Theranostics
2020
A cluster of patients poisoned by herbal medicine in the 1990s revealed that aristolochic acid (AA) causes kidney failure and upper tract urothelial carcinoma (UTUC). Recent research demonstrated that this was not an isolated incident; on the contrary, AA exposure is widespread in East Asia. This editorial highlights research by Lu and colleagues that investigates clinical characteristics of AA and non-AA UTUCs from 90 patients in Beijing based on the AA mutational signature. The study also detected AA mutations in non-tumor tissue of AA exposed patients and showed that AA mutations can be detected in urine, which might form the basis for non-invasive tests for AA exposure.
Duke Scholars
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Published In
Theranostics
DOI
EISSN
1838-7640
Publication Date
2020
Volume
10
Issue
12
Start / End Page
5578 / 5580
Location
Australia
Related Subject Headings
- Urothelium
- Urinary Bladder Neoplasms
- Neoplasm Proteins
- Mutation
- Mutagens
- Humans
- Aristolochic Acids
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Boot, A., Jiang, N., & Rozen, S. G. (2020). Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma. Theranostics, 10(12), 5578–5580. https://doi.org/10.7150/thno.46489
Boot, Arnoud, Nanhai Jiang, and Steven G. Rozen. “Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma.” Theranostics 10, no. 12 (2020): 5578–80. https://doi.org/10.7150/thno.46489.
Boot A, Jiang N, Rozen SG. Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma. Theranostics. 2020;10(12):5578–80.
Boot, Arnoud, et al. “Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma.” Theranostics, vol. 10, no. 12, 2020, pp. 5578–80. Pubmed, doi:10.7150/thno.46489.
Boot A, Jiang N, Rozen SG. Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma. Theranostics. 2020;10(12):5578–5580.
Published In
Theranostics
DOI
EISSN
1838-7640
Publication Date
2020
Volume
10
Issue
12
Start / End Page
5578 / 5580
Location
Australia
Related Subject Headings
- Urothelium
- Urinary Bladder Neoplasms
- Neoplasm Proteins
- Mutation
- Mutagens
- Humans
- Aristolochic Acids
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis