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Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease.

Publication ,  Journal Article
Meyer, T; Rothe, I; Staab, J; Deter, H-C; Fangauf, SV; Hamacher, S; Hellmich, M; Jünger, J; Ladwig, K-H; Michal, M; Petrowski, K; Ronel, J ...
Published in: Biochem Genet
August 2020

Genetic variations affecting the course of depressive symptoms in patients with coronary artery disease (CAD) have not yet been well studied. Therefore, we set out to investigate whether distinct haplotypes of the two insertion/deletion polymorphisms in the serotonin-transporter-linked polymorphic region (5-HTTLPR) and the angiotensin I-converting enzyme (ACE) gene located on chromosome 17 can be identified as risk factors for trajectories of depression. Clinical and genotyping data were derived from 507 depressed CAD patients participating in the randomized, controlled, multicenter Stepwise Psychotherapy Intervention for Reducing Risk in Coronary Artery Disease (SPIRR-CAD) trial, of whom the majority had an acute cardiac event before study inclusion. Depression scores on the Hospital Anxiety and Depression Scale (HADS) were assessed at baseline and at five follow-up time points up to 2 years after study entrance. At baseline, depression scores did not significantly differ between patients carrying the risk haplotype ACE D/D, 5-HTTLPR I/I (n = 46) and the non-risk haplotypes (n = 461, 10.9 ± 2.7 versus 10.4 ± 2.5, p = 0.254). HADS-depression scores declined from study inclusion during the first year irrespective of the genotype. At each follow-up time point, HADS-depression scores were significantly higher in ACE D/D, 5-HTTLPR I/I carriers than in their counterparts. Two years after study inclusion, the mean HADS depression score remained 1.8 points higher in patients with the risk haplotype as compared to subjects not carrying this haplotype (9.9 ± 4.2 versus 8.1 ± 4.0, p = 0.009). In summary, the presence of the ACE D/D, 5-HTTLPR I/I haplotype may be a vulnerability factor for comorbid depressive symptoms in CAD patients.

Duke Scholars

Published In

Biochem Genet

DOI

EISSN

1573-4927

Publication Date

August 2020

Volume

58

Issue

4

Start / End Page

631 / 648

Location

United States

Related Subject Headings

  • Serotonin Plasma Membrane Transport Proteins
  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Polymorphism, Genetic
  • Peptidyl-Dipeptidase A
  • Middle Aged
  • Male
  • Humans
  • Haplotypes
 

Citation

APA
Chicago
ICMJE
MLA
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Meyer, T., Rothe, I., Staab, J., Deter, H.-C., Fangauf, S. V., Hamacher, S., … SPIRR-CAD Investigators, . (2020). Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease. Biochem Genet, 58(4), 631–648. https://doi.org/10.1007/s10528-020-09967-w
Meyer, Thomas, Isabel Rothe, Julia Staab, Hans-Christian Deter, Stella V. Fangauf, Stefanie Hamacher, Martin Hellmich, et al. “Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease.Biochem Genet 58, no. 4 (August 2020): 631–48. https://doi.org/10.1007/s10528-020-09967-w.
Meyer T, Rothe I, Staab J, Deter H-C, Fangauf SV, Hamacher S, Hellmich M, Jünger J, Ladwig K-H, Michal M, Petrowski K, Ronel J, Söllner W, Weber C, de Zwaan M, Williams RB, Albus C, Herrmann-Lingen C, SPIRR-CAD Investigators. Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease. Biochem Genet. 2020 Aug;58(4):631–648.
Journal cover image

Published In

Biochem Genet

DOI

EISSN

1573-4927

Publication Date

August 2020

Volume

58

Issue

4

Start / End Page

631 / 648

Location

United States

Related Subject Headings

  • Serotonin Plasma Membrane Transport Proteins
  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Polymorphism, Genetic
  • Peptidyl-Dipeptidase A
  • Middle Aged
  • Male
  • Humans
  • Haplotypes