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Frailty as a predictor of all-cause mortality and readmission in older patients with acute coronary syndrome : A systematic review and meta-analysis.

Publication ,  Journal Article
Xu, W; Cai, Y; Liu, H; Fan, L; Wu, C
Published in: Wiener klinische Wochenschrift
June 2020

Evidence from longitudinal studies linking frailty and outcome after acute coronary syndrome (ACS) is mixed. This systematic review and meta-analysis aimed to examine whether frailty is a predictor of all-cause mortality and hospital readmission in older patients with ACS.A systematic search was carried out in PubMed, EMBASE and Web of Science databases for studies evaluating the association between frailty and outcomes in older patients with ACS. A meta-analysis was performed to determine the pooled effect estimate for the association between frailty and mortality and hospital readmission, respectively.A total of 1459 articles were retrieved based on our search strategy. Fifteen studies involving 10,245 patients were included in the meta-analysis. The pooled prevalence of frailty was 32% (95% confidence interval [CI]: 25-39%), and the pooled prevalence of pre-frailty was 33% (95% CI: 26-40%) in elderly patients with ACS. Pooled analyses showed that frailty was associated with significantly higher risk of all-cause mortality and readmission (hazard ratios [HRs] = 2.43 and 2.32, respectively). Pre-frailty was also associated with significantly higher risk of all-cause mortality and readmission, respectively (HRs = 1.55 and 1.34, respectively).Both frailty and pre-frailty are risk factors for all-cause mortality and readmission in older patients with ACS. Therefore, frailty assessment should be given sufficient attention in the management of older patients with ACS to help improve survival and reduce readmission rate.

Duke Scholars

Published In

Wiener klinische Wochenschrift

DOI

EISSN

1613-7671

ISSN

0043-5325

Publication Date

June 2020

Volume

132

Issue

11-12

Start / End Page

301 / 309

Related Subject Headings

  • Risk Factors
  • Patient Readmission
  • Humans
  • General Clinical Medicine
  • Frailty
  • Frail Elderly
  • Endocrinology & Metabolism
  • Aged
  • Acute Coronary Syndrome
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Xu, W., Cai, Y., Liu, H., Fan, L., & Wu, C. (2020). Frailty as a predictor of all-cause mortality and readmission in older patients with acute coronary syndrome : A systematic review and meta-analysis. Wiener Klinische Wochenschrift, 132(11–12), 301–309. https://doi.org/10.1007/s00508-020-01650-9
Xu, Weihao, Yulun Cai, Hongbin Liu, Li Fan, and Chenkai Wu. “Frailty as a predictor of all-cause mortality and readmission in older patients with acute coronary syndrome : A systematic review and meta-analysis.Wiener Klinische Wochenschrift 132, no. 11–12 (June 2020): 301–9. https://doi.org/10.1007/s00508-020-01650-9.
Xu, Weihao, et al. “Frailty as a predictor of all-cause mortality and readmission in older patients with acute coronary syndrome : A systematic review and meta-analysis.Wiener Klinische Wochenschrift, vol. 132, no. 11–12, June 2020, pp. 301–09. Epmc, doi:10.1007/s00508-020-01650-9.
Journal cover image

Published In

Wiener klinische Wochenschrift

DOI

EISSN

1613-7671

ISSN

0043-5325

Publication Date

June 2020

Volume

132

Issue

11-12

Start / End Page

301 / 309

Related Subject Headings

  • Risk Factors
  • Patient Readmission
  • Humans
  • General Clinical Medicine
  • Frailty
  • Frail Elderly
  • Endocrinology & Metabolism
  • Aged
  • Acute Coronary Syndrome
  • 3202 Clinical sciences