Skip to main content
Journal cover image

Level and Change in N-Terminal Pro-B-Type Natriuretic Peptide and Kidney Function and Survival to Age 90.

Publication ,  Journal Article
Häberle, AD; Biggs, ML; Cushman, M; Psaty, BM; Newman, AB; Shlipak, MG; Gottdiener, J; Wu, C; Gardin, JM; Bansal, N; Odden, MC
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
February 2021

Many traditional cardiovascular risk factors do not predict survival to very old age. Studies have shown associations of estimated glomerular filtration rate (eGFR) and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) with cardiovascular disease and mortality in older populations. This study aimed to evaluate the associations of the level and change in eGFR and NT-pro-BNP with longevity to age 90 years.The population included participants (n = 3,645) in the Cardiovascular Health Study, aged between 67 and 75 at baseline. The main exposures were eGFR, calculated with the Berlin Initiative Study (BIS) 2 equation, and NT-pro-BNP, and the main outcome was survival to age 90. Mixed models were used to estimate level and change of the main exposures.There was an association between baseline level and change of both eGFR and NT-pro-BNP and survival to 90, and this association persisted after adjustment for covariates. Each 10 mL/min/1.73 m2 higher eGFR level was associated with an adjusted odds ratio (OR) of 1.23 (95% CI: 1.13, 1.34) of survival to 90, and a 0.5 mL/min/1.73 m2 slower decline in eGFR was associated with an OR of 1.51 (95% CI: 1.31, 1.74). A twofold higher level of NT-pro-BNP level had an adjusted OR of 0.67 (95% CI: 0.61, 0.73), and a 1.05-fold increase per year in NT-pro-BNP had an OR of 0.53 (95% CI: 0.43, 0.65) for survival to age 90.eGFR and NT-pro-BNP appear to be important risk factors for longevity to age 90.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

February 2021

Volume

76

Issue

3

Start / End Page

478 / 484

Related Subject Headings

  • Survival Rate
  • Risk Factors
  • Peptide Fragments
  • Odds Ratio
  • Natriuretic Peptide, Brain
  • Male
  • Longevity
  • Kidney Diseases
  • Humans
  • Glomerular Filtration Rate
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Häberle, A. D., Biggs, M. L., Cushman, M., Psaty, B. M., Newman, A. B., Shlipak, M. G., … Odden, M. C. (2021). Level and Change in N-Terminal Pro-B-Type Natriuretic Peptide and Kidney Function and Survival to Age 90. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 76(3), 478–484. https://doi.org/10.1093/gerona/glaa124
Häberle, Astrid D., Mary L. Biggs, Mary Cushman, Bruce M. Psaty, Anne B. Newman, Michael G. Shlipak, John Gottdiener, et al. “Level and Change in N-Terminal Pro-B-Type Natriuretic Peptide and Kidney Function and Survival to Age 90.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 76, no. 3 (February 2021): 478–84. https://doi.org/10.1093/gerona/glaa124.
Häberle AD, Biggs ML, Cushman M, Psaty BM, Newman AB, Shlipak MG, et al. Level and Change in N-Terminal Pro-B-Type Natriuretic Peptide and Kidney Function and Survival to Age 90. The journals of gerontology Series A, Biological sciences and medical sciences. 2021 Feb;76(3):478–84.
Häberle, Astrid D., et al. “Level and Change in N-Terminal Pro-B-Type Natriuretic Peptide and Kidney Function and Survival to Age 90.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 76, no. 3, Feb. 2021, pp. 478–84. Epmc, doi:10.1093/gerona/glaa124.
Häberle AD, Biggs ML, Cushman M, Psaty BM, Newman AB, Shlipak MG, Gottdiener J, Wu C, Gardin JM, Bansal N, Odden MC. Level and Change in N-Terminal Pro-B-Type Natriuretic Peptide and Kidney Function and Survival to Age 90. The journals of gerontology Series A, Biological sciences and medical sciences. 2021 Feb;76(3):478–484.
Journal cover image

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

February 2021

Volume

76

Issue

3

Start / End Page

478 / 484

Related Subject Headings

  • Survival Rate
  • Risk Factors
  • Peptide Fragments
  • Odds Ratio
  • Natriuretic Peptide, Brain
  • Male
  • Longevity
  • Kidney Diseases
  • Humans
  • Glomerular Filtration Rate