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Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report.

Publication ,  Journal Article
Tambur, AR; Campbell, P; Chong, AS; Feng, S; Ford, ML; Gebel, H; Gill, RG; Kelsoe, G; Kosmoliaptsis, V; Mannon, RB; Mengel, M; Reed, EF ...
Published in: Am J Transplant
October 2020

The purpose of the STAR 2019 Working Group was to build on findings from the initial STAR report to further clarify the expectations, limitations, perceptions, and utility of alloimmune assays that are currently in use or in development for risk assessment in the setting of organ transplantation. The goal was to determine the precision and clinical feasibility/utility of such assays in evaluating both memory and primary alloimmune risks. The process included a critical review of biologically driven, state-of-the-art, clinical diagnostics literature by experts in the field and an open public forum in a face-to-face meeting to promote broader engagement of the American Society of Transplantation and American Society of Histocompatibility and Immunogenetics membership. This report summarizes the literature review and the workshop discussions. Specifically, it highlights (1) available assays to evaluate the attributes of HLA antibodies and their utility both as clinical diagnostics and as research tools to evaluate the effector mechanisms driving rejection; (2) potential assays to assess the presence of alloimmune T and B cell memory; and (3) progress in the development of HLA molecular mismatch computational scores as a potential prognostic biomarker for primary alloimmunity and its application in research trial design.

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

October 2020

Volume

20

Issue

10

Start / End Page

2652 / 2668

Location

United States

Related Subject Headings

  • Surgery
  • Kidney Transplantation
  • Isoantibodies
  • Histocompatibility
  • HLA Antigens
  • Group Processes
  • Graft Rejection
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tambur, A. R., Campbell, P., Chong, A. S., Feng, S., Ford, M. L., Gebel, H., … Nickerson, P. (2020). Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report. Am J Transplant, 20(10), 2652–2668. https://doi.org/10.1111/ajt.15937
Tambur, Anat R., Patricia Campbell, Anita S. Chong, Sandy Feng, Mandy L. Ford, Howard Gebel, Ronald G. Gill, et al. “Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report.Am J Transplant 20, no. 10 (October 2020): 2652–68. https://doi.org/10.1111/ajt.15937.
Tambur AR, Campbell P, Chong AS, Feng S, Ford ML, Gebel H, et al. Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report. Am J Transplant. 2020 Oct;20(10):2652–68.
Tambur, Anat R., et al. “Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report.Am J Transplant, vol. 20, no. 10, Oct. 2020, pp. 2652–68. Pubmed, doi:10.1111/ajt.15937.
Tambur AR, Campbell P, Chong AS, Feng S, Ford ML, Gebel H, Gill RG, Kelsoe G, Kosmoliaptsis V, Mannon RB, Mengel M, Reed EF, Valenzuela NM, Wiebe C, Dijke IE, Sullivan HC, Nickerson P. Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report. Am J Transplant. 2020 Oct;20(10):2652–2668.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

October 2020

Volume

20

Issue

10

Start / End Page

2652 / 2668

Location

United States

Related Subject Headings

  • Surgery
  • Kidney Transplantation
  • Isoantibodies
  • Histocompatibility
  • HLA Antigens
  • Group Processes
  • Graft Rejection
  • 3204 Immunology
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences