Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood.

Publication ,  Journal Article
Reuben, A; Sugden, K; Arseneault, L; Corcoran, DL; Danese, A; Fisher, HL; Moffitt, TE; Newbury, JB; Odgers, C; Prinz, J; Rasmussen, LJH ...
Published in: JAMA network open
June 2020

DNA methylation has been proposed as an epigenetic mechanism by which the childhood neighborhood environment may have implications for the genome that compromise adult health.To ascertain whether childhood neighborhood socioeconomic disadvantage is associated with differences in DNA methylation by age 18 years.This longitudinal cohort study analyzed data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative birth cohort of children born between 1994 and 1995 in England and Wales and followed up from age 5 to 18 years. Data analysis was performed from March 15, 2019, to June 30, 2019.High-resolution neighborhood data (indexing deprivation, dilapidation, disconnection, and dangerousness) collected across childhood.DNA methylation in whole blood was drawn at age 18 years. Associations between neighborhood socioeconomic disadvantage and methylation were tested using 3 prespecified approaches: (1) testing probes annotated to candidate genes involved in biological responses to growing up in socioeconomically disadvantaged neighborhoods and investigated in previous epigenetic research (stress reactivity-related and inflammation-related genes), (2) polyepigenetic scores indexing differential methylation in phenotypes associated with growing up in disadvantaged neighborhoods (obesity, inflammation, and smoking), and (3) a theory-free epigenome-wide association study.A total of 1619 participants (806 female individuals [50%]) had complete neighborhood and DNA methylation data. Children raised in socioeconomically disadvantaged neighborhoods exhibited differential DNA methylation in genes involved in inflammation (β = 0.12; 95% CI, 0.06-0.19; P < .001) and smoking (β = 0.18; 95% CI, 0.11-0.25; P < .001) but not obesity (β = 0.05; 95% CI, -0.01 to 0.11; P = .12). An epigenome-wide association study identified multiple CpG sites at an arraywide significance level of P < 1.16 × 10-7 in genes involved in the metabolism of hydrocarbons. Associations between neighborhood disadvantage and methylation were small but robust to family-level socioeconomic factors and to individual-level tobacco smoking.Children raised in more socioeconomically disadvantaged neighborhoods appeared to enter young adulthood epigenetically distinct from their less disadvantaged peers. This finding suggests that epigenetic regulation may be a mechanism by which the childhood neighborhood environment alters adult health.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

JAMA network open

DOI

EISSN

2574-3805

ISSN

2574-3805

Publication Date

June 2020

Volume

3

Issue

6

Start / End Page

e206095

Related Subject Headings

  • Socioeconomic Factors
  • Smoking
  • Residence Characteristics
  • Phenotype
  • Outcome Assessment, Health Care
  • Obesity
  • Male
  • Longitudinal Studies
  • Inflammation
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Reuben, A., Sugden, K., Arseneault, L., Corcoran, D. L., Danese, A., Fisher, H. L., … Caspi, A. (2020). Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood. JAMA Network Open, 3(6), e206095. https://doi.org/10.1001/jamanetworkopen.2020.6095
Reuben, Aaron, Karen Sugden, Louise Arseneault, David L. Corcoran, Andrea Danese, Helen L. Fisher, Terrie E. Moffitt, et al. “Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood.JAMA Network Open 3, no. 6 (June 2020): e206095. https://doi.org/10.1001/jamanetworkopen.2020.6095.
Reuben A, Sugden K, Arseneault L, Corcoran DL, Danese A, Fisher HL, et al. Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood. JAMA network open. 2020 Jun;3(6):e206095.
Reuben, Aaron, et al. “Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood.JAMA Network Open, vol. 3, no. 6, June 2020, p. e206095. Epmc, doi:10.1001/jamanetworkopen.2020.6095.
Reuben A, Sugden K, Arseneault L, Corcoran DL, Danese A, Fisher HL, Moffitt TE, Newbury JB, Odgers C, Prinz J, Rasmussen LJH, Williams B, Mill J, Caspi A. Association of Neighborhood Disadvantage in Childhood With DNA Methylation in Young Adulthood. JAMA network open. 2020 Jun;3(6):e206095.

Published In

JAMA network open

DOI

EISSN

2574-3805

ISSN

2574-3805

Publication Date

June 2020

Volume

3

Issue

6

Start / End Page

e206095

Related Subject Headings

  • Socioeconomic Factors
  • Smoking
  • Residence Characteristics
  • Phenotype
  • Outcome Assessment, Health Care
  • Obesity
  • Male
  • Longitudinal Studies
  • Inflammation
  • Humans