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Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort.

Publication ,  Journal Article
Fernández Hidalgo, N; Gharamti, AA; Aznar, ML; Almirante, B; Yasmin, M; Fortes, CQ; Plesiat, P; Doco-Lecompte, T; Rizk, H; Wray, D; Lamas, C ...
Published in: Open Forum Infect Dis
May 2020

BACKGROUND: Beta-hemolytic streptococci (BHS) are an uncommon cause of infective endocarditis (IE). The aim of this study was to describe the clinical features and outcomes of patients with BHS IE in a large multinational cohort and compare them with patients with viridans streptococcal IE. METHODS: The International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) is a large multinational database that recruited patients with IE prospectively using a standardized data set. Sixty-four sites in 28 countries reported patients prospectively using a standard case report form developed by ICE collaborators. RESULTS: Among 1336 definite cases of streptococcal IE, 823 were caused by VGS and 147 by BHS. Patients with BHS IE had a lower prevalence of native valve (P < .005) and congenital heart disease predisposition (P = .002), but higher prevalence of implantable cardiac device predisposition (P < .005). Clinically, they were more likely to present acutely (P < .005) and with fever (P = .024). BHS IE was more likely to be complicated by stroke and other systemic emboli (P < .005). The overall in-hospital mortality of BHS IE was significantly higher than that of VGS IE (P = .001). In univariate analysis, variables associated with in-hospital mortality for BHS IE were age (odds ratio [OR], 1.044; P = .004), prosthetic valve IE (OR, 3.029; P = .022), congestive heart failure (OR, 2.513; P = .034), and stroke (OR, 3.198; P = .009). CONCLUSIONS: BHS IE is characterized by an acute presentation and higher rate of stroke, systemic emboli, and in-hospital mortality than VGS IE. Implantable cardiac devices as a predisposing factor were more often found in BHS IE compared with VGS IE.

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Published In

Open Forum Infect Dis

DOI

ISSN

2328-8957

Publication Date

May 2020

Volume

7

Issue

5

Start / End Page

ofaa120

Location

United States

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fernández Hidalgo, N., Gharamti, A. A., Aznar, M. L., Almirante, B., Yasmin, M., Fortes, C. Q., … Kanafani, Z. A. (2020). Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort. Open Forum Infect Dis, 7(5), ofaa120. https://doi.org/10.1093/ofid/ofaa120
Fernández Hidalgo, Núria, Amal A. Gharamti, María Luisa Aznar, Benito Almirante, Mohamad Yasmin, Claudio Querido Fortes, Patrick Plesiat, et al. “Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort.Open Forum Infect Dis 7, no. 5 (May 2020): ofaa120. https://doi.org/10.1093/ofid/ofaa120.
Fernández Hidalgo N, Gharamti AA, Aznar ML, Almirante B, Yasmin M, Fortes CQ, et al. Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort. Open Forum Infect Dis. 2020 May;7(5):ofaa120.
Fernández Hidalgo, Núria, et al. “Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort.Open Forum Infect Dis, vol. 7, no. 5, May 2020, p. ofaa120. Pubmed, doi:10.1093/ofid/ofaa120.
Fernández Hidalgo N, Gharamti AA, Aznar ML, Almirante B, Yasmin M, Fortes CQ, Plesiat P, Doco-Lecompte T, Rizk H, Wray D, Lamas C, Durante-Mangoni E, Tattevin P, Snygg-Martin U, Hannan MM, Chu VH, Kanafani ZA. Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort. Open Forum Infect Dis. 2020 May;7(5):ofaa120.
Journal cover image

Published In

Open Forum Infect Dis

DOI

ISSN

2328-8957

Publication Date

May 2020

Volume

7

Issue

5

Start / End Page

ofaa120

Location

United States

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences