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Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research.

Publication ,  Journal Article
Wise, CF; Hammel, SC; Herkert, N; Ma, J; Motsinger-Reif, A; Stapleton, HM; Breen, M
Published in: Environmental science & technology
June 2020

Silicone wristbands are promising passive samplers to support epidemiological studies in characterizing exposure to organic contaminants; however, investigating associated health risks remains challenging because of the latency period for many chronic diseases that take years to manifest. Dogs provide valuable insights as sentinels for exposure-related human disease because they share similar exposures in the home, have shorter life spans, share many clinical/biological features, and have closely related genomes. Here, we evaluated exposures among pet dogs and their owners using silicone dog tags and wristbands to determine if contaminant levels were correlated with validated exposure biomarkers. Significant correlations between measures on dog tags and wristbands were observed (rs = 0.38-0.90; p < 0.05). Correlations with their respective urinary biomarkers were stronger in dog tags compared to that in human wristbands (rs = 0.50-0.71; p < 0.01) for several organophosphate esters. This supports the value of using silicone bands with dogs to investigate health impacts on humans from shared exposures.

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Published In

Environmental science & technology

DOI

EISSN

1520-5851

ISSN

0013-936X

Publication Date

June 2020

Volume

54

Issue

12

Start / End Page

7409 / 7419

Related Subject Headings

  • Silicones
  • Organophosphates
  • Humans
  • Environmental Sciences
  • Environmental Monitoring
  • Dogs
  • Biomarkers
  • Animals
 

Citation

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Wise, C. F., Hammel, S. C., Herkert, N., Ma, J., Motsinger-Reif, A., Stapleton, H. M., & Breen, M. (2020). Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research. Environmental Science & Technology, 54(12), 7409–7419. https://doi.org/10.1021/acs.est.9b06605
Wise, Catherine F., Stephanie C. Hammel, Nicholas Herkert, Jun Ma, Alison Motsinger-Reif, Heather M. Stapleton, and Matthew Breen. “Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research.Environmental Science & Technology 54, no. 12 (June 2020): 7409–19. https://doi.org/10.1021/acs.est.9b06605.
Wise CF, Hammel SC, Herkert N, Ma J, Motsinger-Reif A, Stapleton HM, et al. Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research. Environmental science & technology. 2020 Jun;54(12):7409–19.
Wise, Catherine F., et al. “Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research.Environmental Science & Technology, vol. 54, no. 12, June 2020, pp. 7409–19. Epmc, doi:10.1021/acs.est.9b06605.
Wise CF, Hammel SC, Herkert N, Ma J, Motsinger-Reif A, Stapleton HM, Breen M. Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research. Environmental science & technology. 2020 Jun;54(12):7409–7419.
Journal cover image

Published In

Environmental science & technology

DOI

EISSN

1520-5851

ISSN

0013-936X

Publication Date

June 2020

Volume

54

Issue

12

Start / End Page

7409 / 7419

Related Subject Headings

  • Silicones
  • Organophosphates
  • Humans
  • Environmental Sciences
  • Environmental Monitoring
  • Dogs
  • Biomarkers
  • Animals