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A Narrative Review of Early Oral Stepdown Therapy for the Treatment of Uncomplicated Staphylococcus aureus Bacteremia: Yay or Nay?

Publication ,  Journal Article
Dagher, M; Fowler, VG; Wright, PW; Staub, MB
Published in: Open forum infectious diseases
June 2020

Historically, intravenous (IV) antibiotics have been the cornerstone of treatment for uncomplicated Staphylococcus aureus bacteremia (SAB). However, IV antibiotics are expensive, increase the rates of hospital readmission, and can be associated with catheter-related complications. As a result, the potential role of oral antibiotics in the treatment of uncomplicated SAB has become a subject of interest. This narrative review article aims to summarize key arguments for and against the use of oral antibiotics to complete treatment of uncomplicated SAB and evaluates the available evidence for specific oral regimens. We conclude that evidence suggests that oral step-down therapy can be an alternative for select patients who meet the criteria for uncomplicated SAB and will comply with medical treatment and outpatient follow-up. Of the currently studied regimens discussed in this article, linezolid has the most support, followed by fluoroquinolone plus rifampin.

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Published In

Open forum infectious diseases

DOI

EISSN

2328-8957

ISSN

2328-8957

Publication Date

June 2020

Volume

7

Issue

6

Start / End Page

ofaa151

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences
 

Citation

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Chicago
ICMJE
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Dagher, M., Fowler, V. G., Wright, P. W., & Staub, M. B. (2020). A Narrative Review of Early Oral Stepdown Therapy for the Treatment of Uncomplicated Staphylococcus aureus Bacteremia: Yay or Nay? Open Forum Infectious Diseases, 7(6), ofaa151. https://doi.org/10.1093/ofid/ofaa151
Dagher, Michael, Vance G. Fowler, Patty W. Wright, and Milner B. Staub. “A Narrative Review of Early Oral Stepdown Therapy for the Treatment of Uncomplicated Staphylococcus aureus Bacteremia: Yay or Nay?Open Forum Infectious Diseases 7, no. 6 (June 2020): ofaa151. https://doi.org/10.1093/ofid/ofaa151.
Dagher M, Fowler VG, Wright PW, Staub MB. A Narrative Review of Early Oral Stepdown Therapy for the Treatment of Uncomplicated Staphylococcus aureus Bacteremia: Yay or Nay? Open forum infectious diseases. 2020 Jun;7(6):ofaa151.
Dagher, Michael, et al. “A Narrative Review of Early Oral Stepdown Therapy for the Treatment of Uncomplicated Staphylococcus aureus Bacteremia: Yay or Nay?Open Forum Infectious Diseases, vol. 7, no. 6, June 2020, p. ofaa151. Epmc, doi:10.1093/ofid/ofaa151.
Dagher M, Fowler VG, Wright PW, Staub MB. A Narrative Review of Early Oral Stepdown Therapy for the Treatment of Uncomplicated Staphylococcus aureus Bacteremia: Yay or Nay? Open forum infectious diseases. 2020 Jun;7(6):ofaa151.
Journal cover image

Published In

Open forum infectious diseases

DOI

EISSN

2328-8957

ISSN

2328-8957

Publication Date

June 2020

Volume

7

Issue

6

Start / End Page

ofaa151

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences