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Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide-field optical coherence tomography in Singapore adults with high myopia.

Publication ,  Journal Article
Zheng, F; Wong, C-W; Sabanayagam, C; Cheung, Y-B; Matsumura, S; Chua, J; Man, REK; Ohno-Matsui, K; Wong, T-Y; Cheng, C-Y; Tai, ES; Kuo, A ...
Published in: Acta Ophthalmol
March 2021

PURPOSE: To investigate the prevalence and risk factors of posterior staphyloma using wide-field optical coherence tomography (WF-OCT) in adults with high myopia in Singapore. DESIGN: Population-based cross-sectional study. METHODS: Adults with spherical equivalent (SE) ≤ -5D in either eye at the first visit of Singapore Epidemiology of Eye Diseases study and Singapore Prospective Study Program study were recruited. Posterior staphyloma was diagnosed using WF-OCT (PLEX® Elite9000, Carl Zeiss Meditec). Myopic macular degeneration (MMD), myopic traction maculopathy (MTM) and vision-related quality of life (VRQoL) were assessed using fundus photographs, DRI-Triton OCT (Topcon) and the Impact of Vision Impairment (IVI) questionnaire, respectively. Factors associated with posterior staphyloma were identified with multilevel, multivariable logistic regression. Impact of posterior staphyloma on MMD, MTM and visual function was analysed with multilevel, multivariable logistic regression and linear mixed model, respectively. RESULTS: Among the 225 eyes [mean SE = -6.5 ± 2.2 D, mean axial length (AL) = 26.2 ± 1.5 mm] of 117 participants (mean age = 60.3 ± 7.1 years), posterior staphyloma was detected in 47 (20.9%) eyes of 38 (32.5%) participants. Older age [odds ratio (OR), 1.18; 95% confidence interval (CI), 1.10-1.26], more myopic SE (0.63; 0.51-0.77) and increased AL (2.51; 1.69-3.73) were associated with higher prevalence of posterior staphyloma (all p < 0.001). Adults with posterior staphyloma had higher odds of MMD (2.67; 1.23-5.82; p = 0.013), MTM (3.79; 1.13-12.68; p = 0.031) and worse IVI Reading (β = -1.44; -2.31 to 0.58; p = 0.001) scores. CONCLUSIONS: About one in three adults with high myopia had posterior staphyloma, which was associated with increased odds of having myopic maculopathy and a detrimental impact on VRQoL.

Duke Scholars

Published In

Acta Ophthalmol

DOI

EISSN

1755-3768

Publication Date

March 2021

Volume

99

Issue

2

Start / End Page

e144 / e153

Location

England

Related Subject Headings

  • Visual Acuity
  • Tomography, Optical Coherence
  • Singapore
  • Scleral Diseases
  • Sclera
  • Risk Factors
  • Refraction, Ocular
  • Quality of Life
  • Prospective Studies
  • Prevalence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zheng, F., Wong, C.-W., Sabanayagam, C., Cheung, Y.-B., Matsumura, S., Chua, J., … Saw, S.-M. (2021). Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide-field optical coherence tomography in Singapore adults with high myopia. Acta Ophthalmol, 99(2), e144–e153. https://doi.org/10.1111/aos.14527
Zheng, Feihui, Chee-Wai Wong, Charumathi Sabanayagam, Yin-Bun Cheung, Saiko Matsumura, Jacqueline Chua, Ryan Eyn Kidd Man, et al. “Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide-field optical coherence tomography in Singapore adults with high myopia.Acta Ophthalmol 99, no. 2 (March 2021): e144–53. https://doi.org/10.1111/aos.14527.
Zheng F, Wong C-W, Sabanayagam C, Cheung Y-B, Matsumura S, Chua J, et al. Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide-field optical coherence tomography in Singapore adults with high myopia. Acta Ophthalmol. 2021 Mar;99(2):e144–53.
Zheng, Feihui, et al. “Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide-field optical coherence tomography in Singapore adults with high myopia.Acta Ophthalmol, vol. 99, no. 2, Mar. 2021, pp. e144–53. Pubmed, doi:10.1111/aos.14527.
Zheng F, Wong C-W, Sabanayagam C, Cheung Y-B, Matsumura S, Chua J, Man REK, Ohno-Matsui K, Wong T-Y, Cheng C-Y, Tai ES, Lamoureux ELED, Schmetterer L, Kuo A, Hoang QV, Saw S-M. Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide-field optical coherence tomography in Singapore adults with high myopia. Acta Ophthalmol. 2021 Mar;99(2):e144–e153.
Journal cover image

Published In

Acta Ophthalmol

DOI

EISSN

1755-3768

Publication Date

March 2021

Volume

99

Issue

2

Start / End Page

e144 / e153

Location

England

Related Subject Headings

  • Visual Acuity
  • Tomography, Optical Coherence
  • Singapore
  • Scleral Diseases
  • Sclera
  • Risk Factors
  • Refraction, Ocular
  • Quality of Life
  • Prospective Studies
  • Prevalence