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COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors.

Publication ,  Journal Article
Ragnesola, B; Jin, D; Lamb, CC; Shaz, BH; Hillyer, CD; Luchsinger, LL
Published in: BMC Res Notes
August 6, 2020

OBJECTIVE: COVID19 has caused a global and ongoing pandemic. The need for population seroconversion data is apparent to monitor and respond to the pandemic. Using a lateral flow assay (LFA) testing platform, the seropositivity in 63 New York Blood Center (NYBC) Convelescent Plasma (CP) donor samples were evaluated for the presence of COVID19 specific IgG and IgM. RESULTS: CP donors showed diverse antibody result. Convalescent donor plasma contains SARS-CoV-2 specific antibodies. Weak antibody bands may identify low titer CP donors. LFA tests can identify antibody positive individuals that have recovered from COVID19. Confirming suspected cases using antibody detection could help inform the patient and the community as to the relative risk to future exposure and a better understanding of disease exposure.

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Published In

BMC Res Notes

DOI

EISSN

1756-0500

Publication Date

August 6, 2020

Volume

13

Issue

1

Start / End Page

372

Location

England

Related Subject Headings

  • Spike Glycoprotein, Coronavirus
  • Seroconversion
  • Sensitivity and Specificity
  • SARS-CoV-2
  • Reproducibility of Results
  • Recombinant Proteins
  • Protein Domains
  • Point-of-Care Testing
  • Pneumonia, Viral
  • Plasma
 

Citation

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Ragnesola, B., Jin, D., Lamb, C. C., Shaz, B. H., Hillyer, C. D., & Luchsinger, L. L. (2020). COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors. BMC Res Notes, 13(1), 372. https://doi.org/10.1186/s13104-020-05212-0
Ragnesola, Brett, Daniel Jin, Christopher C. Lamb, Beth H. Shaz, Christopher D. Hillyer, and Larry L. Luchsinger. “COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors.BMC Res Notes 13, no. 1 (August 6, 2020): 372. https://doi.org/10.1186/s13104-020-05212-0.
Ragnesola B, Jin D, Lamb CC, Shaz BH, Hillyer CD, Luchsinger LL. COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors. BMC Res Notes. 2020 Aug 6;13(1):372.
Ragnesola, Brett, et al. “COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors.BMC Res Notes, vol. 13, no. 1, Aug. 2020, p. 372. Pubmed, doi:10.1186/s13104-020-05212-0.
Ragnesola B, Jin D, Lamb CC, Shaz BH, Hillyer CD, Luchsinger LL. COVID19 antibody detection using lateral flow assay tests in a cohort of convalescent plasma donors. BMC Res Notes. 2020 Aug 6;13(1):372.
Journal cover image

Published In

BMC Res Notes

DOI

EISSN

1756-0500

Publication Date

August 6, 2020

Volume

13

Issue

1

Start / End Page

372

Location

England

Related Subject Headings

  • Spike Glycoprotein, Coronavirus
  • Seroconversion
  • Sensitivity and Specificity
  • SARS-CoV-2
  • Reproducibility of Results
  • Recombinant Proteins
  • Protein Domains
  • Point-of-Care Testing
  • Pneumonia, Viral
  • Plasma