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Seasonal variability is not observed in the rates of high anti-A and anti-B titers in plasma, apheresis platelet, and whole blood units tested by different methods.

Publication ,  Journal Article
Harm, SK; Yazer, MH; Bub, CB; Cohn, CS; Jacob, EK; Kutner, JM; Mair, DC; Raval, JS; Shaz, BH; Ziman, A; Dunbar, NM ...
Published in: Transfusion
February 2019

BACKGROUND: ABO-incompatible platelet transfusions are common, and transfusions with ABO-incompatible plasma are increasing with the use of group A plasma and group O whole blood (WB) in emergencies. Many centers screen blood products for anti-A and/or anti-B titers to help prevent hemolysis from ABO-incompatible transfusions, yet titer methods and definition of high titers are not standardized. STUDY DESIGN AND METHODS: This international multicenter study collected data on anti-A and anti-B titer practices for plasma, apheresis platelet (AP), and WB units from January 2015 through December 2017 to determine the prevalence of high-titer units using local definitions. RESULTS: A total of 87,701 plasma, AP and WB units were screened for high-titer anti-A and/or anti-B. High-titer detection rates for group A plasma ranged 0%-13.6%; group A AP 2.7%-9.3%; group O AP 2.3%-65.7%; and group O WB 6.4%-20.7%. At the one center that collected group B AP, the high-titer rate was 10.9%. High-titer rates varied from month to month, as well as between years for a given month. There was no clear pattern of when high-titer units were donated. CONCLUSION: The prevalence of high-titer plasma, AP, and WB units varies by titer method and local definition of high titer. Even at the lowest titer threshold of 50, a significant proportion of units had a high-titer antibody, although the clinical relevance of this finding needs further investigation.

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Published In

Transfusion

DOI

EISSN

1537-2995

Publication Date

February 2019

Volume

59

Issue

2

Start / End Page

762 / 767

Location

United States

Related Subject Headings

  • Transfusion Reaction
  • Seasons
  • Plateletpheresis
  • Platelet Transfusion
  • Male
  • Isoantibodies
  • Humans
  • Female
  • Cardiovascular System & Hematology
  • Blood Group Incompatibility
 

Citation

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Chicago
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Harm, S. K., Yazer, M. H., Bub, C. B., Cohn, C. S., Jacob, E. K., Kutner, J. M., … Biomedical Excellence for Safer Transfusion (BEST) Collaborative, . (2019). Seasonal variability is not observed in the rates of high anti-A and anti-B titers in plasma, apheresis platelet, and whole blood units tested by different methods. Transfusion, 59(2), 762–767. https://doi.org/10.1111/trf.15083
Harm, Sarah K., Mark H. Yazer, Carolina B. Bub, Claudia S. Cohn, Eapen K. Jacob, Jose M. Kutner, David C. Mair, et al. “Seasonal variability is not observed in the rates of high anti-A and anti-B titers in plasma, apheresis platelet, and whole blood units tested by different methods.Transfusion 59, no. 2 (February 2019): 762–67. https://doi.org/10.1111/trf.15083.
Harm, Sarah K., et al. “Seasonal variability is not observed in the rates of high anti-A and anti-B titers in plasma, apheresis platelet, and whole blood units tested by different methods.Transfusion, vol. 59, no. 2, Feb. 2019, pp. 762–67. Pubmed, doi:10.1111/trf.15083.
Harm SK, Yazer MH, Bub CB, Cohn CS, Jacob EK, Kutner JM, Mair DC, Raval JS, Shaz BH, Ziman A, Dunbar NM, Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Seasonal variability is not observed in the rates of high anti-A and anti-B titers in plasma, apheresis platelet, and whole blood units tested by different methods. Transfusion. 2019 Feb;59(2):762–767.
Journal cover image

Published In

Transfusion

DOI

EISSN

1537-2995

Publication Date

February 2019

Volume

59

Issue

2

Start / End Page

762 / 767

Location

United States

Related Subject Headings

  • Transfusion Reaction
  • Seasons
  • Plateletpheresis
  • Platelet Transfusion
  • Male
  • Isoantibodies
  • Humans
  • Female
  • Cardiovascular System & Hematology
  • Blood Group Incompatibility