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A comparison of adverse reaction rates for PAS C versus plasma platelet units.

Publication ,  Journal Article
Cohn, CS; Stubbs, J; Schwartz, J; Francis, R; Goss, C; Cushing, M; Shaz, B; Mair, D; Brantigan, B; Heaton, WA
Published in: Transfusion
August 2014

BACKGROUND: Plasma constituents have been implicated in some types of platelet (PLT) transfusion reactions. Leukoreduced apheresis PLTs stored in InterSol have 65% less plasma than apheresis PLTs stored in 100% plasma (PPs). This study compared transfusion reaction rates in InterSol PLTs (PLT additive solution [PAS] C) versus PPs. STUDY DESIGN AND METHODS: The study design was an open-label, nonrandomized retrospective review. Statistical methods were applied to substantiate noninferiority and superiority of PAS C compared to PP in terms of transfusion reaction rates. Adverse reactions (ARs) were categorized using the Biovigilance Component of the National Healthcare Safety Network. Active surveillance was used to monitor all transfusions, both with ARs and without ARs. RESULTS: A total of 14,005 transfusions from six study sites were included, with 9845 PP transfusions given to 2202 patients and 4160 PAS C to 1444 patients. A total of 165 ARs were reported. Percentages of transfusions with ARs were 1.37% for PPs, 0.55% for PAS C, and 1.13% overall. The relative risk (RR) for PAS C versus PPs was calculated as 0.403 with an upper confidence limit (UCL) of 0.663. Overall, ARs with the highest incidence were allergic transfusion reactions (ATRs) and febrile nonhemolytic transfusion reactions (FNHTRs), at 0.66 and 0.40% of total transfusions reported, respectively. The relative risks (UCLs) for ATRs and FNHTRs, respectively, were 0.350 (0.686) and 0.336 (0.827). CONCLUSIONS: PAS C PLTs were statistically superior and noninferior to PPs with respect to the transfusion-related AR rate. PAS C noninferiority and superiority were also demonstrated for ATRs and FNHTRs, separately.

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Published In

Transfusion

DOI

EISSN

1537-2995

Publication Date

August 2014

Volume

54

Issue

8

Start / End Page

1927 / 1934

Location

United States

Related Subject Headings

  • Young Adult
  • Solutions
  • Risk
  • Retrospective Studies
  • Plateletpheresis
  • Platelet Transfusion
  • Plasma
  • Middle Aged
  • Male
  • Infant, Newborn
 

Citation

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ICMJE
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Cohn, C. S., Stubbs, J., Schwartz, J., Francis, R., Goss, C., Cushing, M., … Heaton, W. A. (2014). A comparison of adverse reaction rates for PAS C versus plasma platelet units. Transfusion, 54(8), 1927–1934. https://doi.org/10.1111/trf.12597
Cohn, Claudia S., James Stubbs, Joseph Schwartz, Richard Francis, Cheryl Goss, Melissa Cushing, Beth Shaz, David Mair, Barbara Brantigan, and W Andrew Heaton. “A comparison of adverse reaction rates for PAS C versus plasma platelet units.Transfusion 54, no. 8 (August 2014): 1927–34. https://doi.org/10.1111/trf.12597.
Cohn CS, Stubbs J, Schwartz J, Francis R, Goss C, Cushing M, et al. A comparison of adverse reaction rates for PAS C versus plasma platelet units. Transfusion. 2014 Aug;54(8):1927–34.
Cohn, Claudia S., et al. “A comparison of adverse reaction rates for PAS C versus plasma platelet units.Transfusion, vol. 54, no. 8, Aug. 2014, pp. 1927–34. Pubmed, doi:10.1111/trf.12597.
Cohn CS, Stubbs J, Schwartz J, Francis R, Goss C, Cushing M, Shaz B, Mair D, Brantigan B, Heaton WA. A comparison of adverse reaction rates for PAS C versus plasma platelet units. Transfusion. 2014 Aug;54(8):1927–1934.
Journal cover image

Published In

Transfusion

DOI

EISSN

1537-2995

Publication Date

August 2014

Volume

54

Issue

8

Start / End Page

1927 / 1934

Location

United States

Related Subject Headings

  • Young Adult
  • Solutions
  • Risk
  • Retrospective Studies
  • Plateletpheresis
  • Platelet Transfusion
  • Plasma
  • Middle Aged
  • Male
  • Infant, Newborn