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Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity

Publication ,  Journal Article
Yarasheski, KE; Cade, WT; Overton, ET; Mondy, KE; Hubert, S; Laciny, E; Bopp, C; Lassa-Claxton, S; Reeds, DN
Published in: American Journal of Physiology-Endocrinology and Metabolism
January 2011

The prevalence and incidence of insulin resistance and type 2 diabetes mellitus (DM) are higher in people treated for human immunodeficiency virus-1 (HIV) infection than in the general population. Identifying safe and effective interventions is a high priority. We evaluated whether the peroxisome proliferator-activated receptor-γ agonist pioglitazone with exercise training improves central and peripheral insulin sensitivity more than pioglitazone alone in HIV-infected adults with insulin resistance and central adiposity. Forty-four HIV-infected adults with baseline insulin resistance and central adiposity were randomly assigned to 4 mo of pioglitazone (30 mg/day) with or without supervised, progressive aerobic, and resistance exercise training (1.5–2 h/day, 3 days/wk). The hyperinsulinemic euglycemic clamp was used to evaluate alterations in central and peripheral insulin sensitivity. Thirty-nine participants completed the study. Hepatic insulin sensitivity improved similarly in both groups. Exercise training augmented the beneficial effects of pioglitazone on peripheral insulin sensitivity. Greater improvements in peripheral insulin sensitivity were associated with reductions in total body and limb adipose content rather than increases in limb adiposity or pioglitazone-induced increases in adiponectin concentration. We conclude that supplementing pioglitazone with increased physical activity improved insulin sensitivity more effectively than pioglitazone alone in HIV-infected adults with insulin resistance and central adiposity. Pioglitazone alone did not significantly increase limb adipose content. Potential cardiovascular benefits of these interventions in HIV need investigation.

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Published In

American Journal of Physiology-Endocrinology and Metabolism

DOI

EISSN

1522-1555

ISSN

0193-1849

Publication Date

January 2011

Volume

300

Issue

1

Start / End Page

E243 / E251

Publisher

American Physiological Society

Related Subject Headings

  • Endocrinology & Metabolism
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Yarasheski, K. E., Cade, W. T., Overton, E. T., Mondy, K. E., Hubert, S., Laciny, E., … Reeds, D. N. (2011). Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity. American Journal of Physiology-Endocrinology and Metabolism, 300(1), E243–E251. https://doi.org/10.1152/ajpendo.00468.2010
Yarasheski, Kevin E., W Todd Cade, E Turner Overton, Kristin E. Mondy, Sara Hubert, Erin Laciny, Coco Bopp, Sherry Lassa-Claxton, and Dominic N. Reeds. “Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity.” American Journal of Physiology-Endocrinology and Metabolism 300, no. 1 (January 2011): E243–51. https://doi.org/10.1152/ajpendo.00468.2010.
Yarasheski KE, Cade WT, Overton ET, Mondy KE, Hubert S, Laciny E, et al. Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity. American Journal of Physiology-Endocrinology and Metabolism. 2011 Jan;300(1):E243–51.
Yarasheski, Kevin E., et al. “Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity.” American Journal of Physiology-Endocrinology and Metabolism, vol. 300, no. 1, American Physiological Society, Jan. 2011, pp. E243–51. Crossref, doi:10.1152/ajpendo.00468.2010.
Yarasheski KE, Cade WT, Overton ET, Mondy KE, Hubert S, Laciny E, Bopp C, Lassa-Claxton S, Reeds DN. Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity. American Journal of Physiology-Endocrinology and Metabolism. American Physiological Society; 2011 Jan;300(1):E243–E251.

Published In

American Journal of Physiology-Endocrinology and Metabolism

DOI

EISSN

1522-1555

ISSN

0193-1849

Publication Date

January 2011

Volume

300

Issue

1

Start / End Page

E243 / E251

Publisher

American Physiological Society

Related Subject Headings

  • Endocrinology & Metabolism
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences