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Viscoelastic properties of clot formation and their clinical impact in East Asian versus Caucasian patients with stable coronary artery disease: a COMPARE-RACE analysis.

Publication ,  Journal Article
Jeong, Y-H; Kevin, B; Ahn, J-H; Chaudhary, R; Kang, MG; Park, HW; Koh, J-S; Park, Y; Tantry, US; Gurbel, PA
Published in: J Thromb Thrombolysis
February 2021

Compared with Caucasian patients, East Asian patients with coronary artery disease (CAD) have demonstrated better clinical outcomes. We sought to compare the viscoelastic properties of clot formation and their impact on clinical outcomes in East Asian vs. Caucasian patients. We analyzed age- and sex-matched East Asian and Caucasian patients with stable CAD (n = 249 each). Viscoelastic properties of clot formation were assessed with thromboelastography (TEG), and 3-year clinical outcomes were recorded. Major adverse cardiovascular events (MACE) were defined as a composite of cardiovascular death, myocardial infarction, or stroke. Compared with Caucasians, East Asians showed lower platelet-fibrin clot strength (PFCS) (maximum amplitude [MA]: 61.8 ± 7.9 vs. 65.4 ± 5.0 mm, p < 0.001). In a multivariate analysis, high PFCS (defined as MA ≥ 68 mm) was significantly associated with MACE occurrence (odds ratio 6.27, 95% CI 2.41 to 16.30, p < 0.001). East Asians vs. Caucasians had lower prevalence of high PFCS (odds ratio 0.50, 95% CI 0.27 to 0.93, p = 0.028). In conclusion, this is the first study to demonstrate different viscoelastic properties of clot between East Asian and Caucasian patients with stable CAD. The platelet-fibrin clot strength was significantly associated with MACE in these patients and was significantly lower in East Asians. Future studies are warranted to further explore the mechanistic explanation and clinical importance of these findings.

Duke Scholars

Published In

J Thromb Thrombolysis

DOI

EISSN

1573-742X

Publication Date

February 2021

Volume

51

Issue

2

Start / End Page

454 / 465

Location

Netherlands

Related Subject Headings

  • White People
  • Thrombosis
  • Thrombelastography
  • Sex Factors
  • Middle Aged
  • Male
  • Humans
  • Female
  • Coronary Artery Disease
  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
ICMJE
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Jeong, Y.-H., Kevin, B., Ahn, J.-H., Chaudhary, R., Kang, M. G., Park, H. W., … Gurbel, P. A. (2021). Viscoelastic properties of clot formation and their clinical impact in East Asian versus Caucasian patients with stable coronary artery disease: a COMPARE-RACE analysis. J Thromb Thrombolysis, 51(2), 454–465. https://doi.org/10.1007/s11239-020-02240-2
Jeong, Young-Hoon, Bliden Kevin, Jong-Hwa Ahn, Rahul Chaudhary, Min Gyu Kang, Hyun Woong Park, Jin-Sin Koh, Yongwhi Park, Udaya S. Tantry, and Paul A. Gurbel. “Viscoelastic properties of clot formation and their clinical impact in East Asian versus Caucasian patients with stable coronary artery disease: a COMPARE-RACE analysis.J Thromb Thrombolysis 51, no. 2 (February 2021): 454–65. https://doi.org/10.1007/s11239-020-02240-2.
Jeong Y-H, Kevin B, Ahn J-H, Chaudhary R, Kang MG, Park HW, et al. Viscoelastic properties of clot formation and their clinical impact in East Asian versus Caucasian patients with stable coronary artery disease: a COMPARE-RACE analysis. J Thromb Thrombolysis. 2021 Feb;51(2):454–65.
Jeong, Young-Hoon, et al. “Viscoelastic properties of clot formation and their clinical impact in East Asian versus Caucasian patients with stable coronary artery disease: a COMPARE-RACE analysis.J Thromb Thrombolysis, vol. 51, no. 2, Feb. 2021, pp. 454–65. Pubmed, doi:10.1007/s11239-020-02240-2.
Jeong Y-H, Kevin B, Ahn J-H, Chaudhary R, Kang MG, Park HW, Koh J-S, Park Y, Tantry US, Gurbel PA. Viscoelastic properties of clot formation and their clinical impact in East Asian versus Caucasian patients with stable coronary artery disease: a COMPARE-RACE analysis. J Thromb Thrombolysis. 2021 Feb;51(2):454–465.
Journal cover image

Published In

J Thromb Thrombolysis

DOI

EISSN

1573-742X

Publication Date

February 2021

Volume

51

Issue

2

Start / End Page

454 / 465

Location

Netherlands

Related Subject Headings

  • White People
  • Thrombosis
  • Thrombelastography
  • Sex Factors
  • Middle Aged
  • Male
  • Humans
  • Female
  • Coronary Artery Disease
  • Cardiovascular System & Hematology