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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.

Publication ,  Journal Article
Hofer, E; Roshchupkin, GV; Adams, HHH; Knol, MJ; Lin, H; Li, S; Zare, H; Ahmad, S; Armstrong, NJ; Satizabal, CL; Bernard, M; Bis, JC; Xia, R ...
Published in: Nat Commun
September 22, 2020

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

September 22, 2020

Volume

11

Issue

1

Start / End Page

4796

Location

England

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Phenotype
  • Neurodegenerative Diseases
  • Middle Aged
  • Mental Disorders
  • Male
  • Humans
  • Genomics
  • Genome-Wide Association Study
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Hofer, E., Roshchupkin, G. V., Adams, H. H. H., Knol, M. J., Lin, H., Li, S., … Seshadri, S. (2020). Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nat Commun, 11(1), 4796. https://doi.org/10.1038/s41467-020-18367-y
Hofer, Edith, Gennady V. Roshchupkin, Hieab H. H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, et al. “Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.Nat Commun 11, no. 1 (September 22, 2020): 4796. https://doi.org/10.1038/s41467-020-18367-y.
Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, et al. Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nat Commun. 2020 Sep 22;11(1):4796.
Hofer, Edith, et al. “Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.Nat Commun, vol. 11, no. 1, Sept. 2020, p. 4796. Pubmed, doi:10.1038/s41467-020-18367-y.
Hofer E, Roshchupkin GV, Adams HHH, Knol MJ, Lin H, Li S, Zare H, Ahmad S, Armstrong NJ, Satizabal CL, Bernard M, Bis JC, Gillespie NA, Luciano M, Mishra A, Scholz M, Teumer A, Xia R, Jian X, Mosley TH, Saba Y, Pirpamer L, Seiler S, Becker JT, Carmichael O, Rotter JI, Psaty BM, Lopez OL, Amin N, van der Lee SJ, Yang Q, Himali JJ, Maillard P, Beiser AS, DeCarli C, Karama S, Lewis L, Harris M, Bastin ME, Deary IJ, Veronica Witte A, Beyer F, Loeffler M, Mather KA, Schofield PR, Thalamuthu A, Kwok JB, Wright MJ, Ames D, Trollor J, Jiang J, Brodaty H, Wen W, Vernooij MW, Hofman A, Uitterlinden AG, Niessen WJ, Wittfeld K, Bülow R, Völker U, Pausova Z, Bruce Pike G, Maingault S, Crivello F, Tzourio C, Amouyel P, Mazoyer B, Neale MC, Franz CE, Lyons MJ, Panizzon MS, Andreassen OA, Dale AM, Logue M, Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Stein JL, Thompson PM, Medland SE, ENIGMA consortium, Sachdev PS, Kremen WS, Wardlaw JM, Villringer A, van Duijn CM, Grabe HJ, Longstreth WT, Fornage M, Paus T, Debette S, Ikram MA, Schmidt H, Schmidt R, Seshadri S. Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults. Nat Commun. 2020 Sep 22;11(1):4796.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

September 22, 2020

Volume

11

Issue

1

Start / End Page

4796

Location

England

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Phenotype
  • Neurodegenerative Diseases
  • Middle Aged
  • Mental Disorders
  • Male
  • Humans
  • Genomics
  • Genome-Wide Association Study
  • Female