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Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies.

Publication ,  Journal Article
Modugno, F; Fu, Z; Jordan, SJ; Group, A; Chang-Claude, J; Fortner, RT; Goodman, MT; Moysich, KB; Schildkraut, JM; Berchuck, A; Bandera, EV ...
Published in: Eur J Epidemiol
November 2020

While childbearing protects against risk of epithelial ovarian cancer (EOC), few studies have explored the impact on maternal EOC risk of sex of offspring, which may affect the maternal environment during pregnancy. We performed a pooled analysis among parous participants from 12 case-controls studies comprising 6872 EOC patients and 9101 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression for case-control associations and polytomous logistic regression for histotype-specific associations, all adjusted for potential confounders. In general, no associations were found between offspring sex and EOC risk. However, compared to bearing only female offspring, bearing one or more male offspring was associated with increased risk of mucinous EOC (OR = 1.45; 95% CI = 1.01-2.07), which appeared to be limited to women reporting menarche before age 13 compared to later menarche (OR = 1.71 vs 0.99; P-interaction = 0.02). Bearing increasing numbers of male offspring was associated with greater risks of mucinous tumors (OR = 1.31, 1.84, 2.31, for 1, 2 and 3 or more male offspring, respectively; trend-p = 0.005). Stratifying by hormonally-associated conditions suggested that compared to bearing all female offspring, bearing a male offspring was associated with lower risk of endometrioid cancer among women with a history of adult acne, hirsutism, or polycystic ovary syndrome (OR = 0.49, 95% CI = 0.28-0.83) but with higher risk among women without any of those conditions (OR = 1.64 95% CI = 1.14-2.34; P-interaction = 0.003). Offspring sex influences the childbearing-EOC risk relationship for specific histotypes and conditions. These findings support the differing etiologic origins of EOC histotypes and highlight the importance of EOC histotype-specific epidemiologic studies. These findings also suggest the need to better understand how pregnancy affects EOC risk.

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Published In

Eur J Epidemiol

DOI

EISSN

1573-7284

Publication Date

November 2020

Volume

35

Issue

11

Start / End Page

1025 / 1042

Location

Netherlands

Related Subject Headings

  • Pregnancy
  • Ovarian Neoplasms
  • Middle Aged
  • Male
  • Infant, Newborn
  • Humans
  • Gender Identity
  • Female
  • Epidemiology
  • Endometriosis
 

Citation

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Modugno, F., Fu, Z., Jordan, S. J., Group, A., Chang-Claude, J., Fortner, R. T., … Webb, P. M. (2020). Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies. Eur J Epidemiol, 35(11), 1025–1042. https://doi.org/10.1007/s10654-020-00682-9
Modugno, Francesmary, Zhuxuan Fu, Susan J. Jordan, Aocs Group, Jenny Chang-Claude, Renée T. Fortner, Marc T. Goodman, et al. “Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies.Eur J Epidemiol 35, no. 11 (November 2020): 1025–42. https://doi.org/10.1007/s10654-020-00682-9.
Modugno F, Fu Z, Jordan SJ, Group A, Chang-Claude J, Fortner RT, et al. Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies. Eur J Epidemiol. 2020 Nov;35(11):1025–42.
Modugno, Francesmary, et al. “Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies.Eur J Epidemiol, vol. 35, no. 11, Nov. 2020, pp. 1025–42. Pubmed, doi:10.1007/s10654-020-00682-9.
Modugno F, Fu Z, Jordan SJ, Group A, Chang-Claude J, Fortner RT, Goodman MT, Moysich KB, Schildkraut JM, Berchuck A, Bandera EV, Qin B, Sutphen R, McLaughlin JR, Menon U, Ramus SJ, Gayther SA, Gentry-Maharaj A, Karpinskyj C, Pearce CL, Wu AH, Risch HA, Webb PM. Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case-control studies. Eur J Epidemiol. 2020 Nov;35(11):1025–1042.
Journal cover image

Published In

Eur J Epidemiol

DOI

EISSN

1573-7284

Publication Date

November 2020

Volume

35

Issue

11

Start / End Page

1025 / 1042

Location

Netherlands

Related Subject Headings

  • Pregnancy
  • Ovarian Neoplasms
  • Middle Aged
  • Male
  • Infant, Newborn
  • Humans
  • Gender Identity
  • Female
  • Epidemiology
  • Endometriosis