Skip to main content
Journal cover image

Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study.

Publication ,  Journal Article
Oyedeji, CI; Hall, K; Luciano, A; Morey, MC; Strouse, JJ
Published in: Pilot Feasibility Stud
2020

BACKGROUND: The life expectancy for people with sickle cell disease (SCD) has improved tremendously over the last 50 years. This population experiences hemolysis and vaso-occlusion in multiple organs that lead to complications such as cardiopulmonary disease, strokes, and avascular necrosis. These complications can limit mobility and aerobic endurance, similar to limitations that often occur in geriatric populations. These sickle-cell and age-related events lead to frequent hospitalization, which further increases the risk of functional decline. We have few tools to measure functional decline in people with SCD. The purpose of this paper is to describe a protocol to evaluate the feasibility of sickle cell disease geriatric assessment (SCD-GA). METHODS/DESIGN: We will enroll 40 adults with SCD (20 age 18-49.99 years and 20 age ≥ 50 years) in a prospective cohort study to assess the feasibility of SCD-GA. The SCD-GA includes validated measures from the oncology geriatric assessment enriched with additional physical and cognitive measures. The SCD-GA will be performed at the first study visit, at 10 to 20 days after hospitalization, and at 12 months (exit visit). With input from a multidisciplinary team of sickle cell specialists, geriatricians, and experts in physical function and physical activity, we selected assessments across 7 domains: functional status (11 measures), comorbid medical conditions (1 measure), psychological state (1 measure), social support (2 measures), weight status (2 measures), cognition (3 measures), and medications (1 measure). We will measure the proportion completing the assessment with feasibility as the primary outcome. Secondary outcomes include the proportion consenting and completing all study visits, duration of the assessment, acceptability, and adverse events. DISCUSSION: We present the protocol and rationale for selection of the measures included in SCD-GA. We also outline the methods to determine feasibility and subsequently to optimize the SCD-GA in preparation for a larger multicenter validation study of the SCD-GA.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pilot Feasibility Stud

DOI

ISSN

2055-5784

Publication Date

2020

Volume

6

Start / End Page

131

Location

England

Related Subject Headings

  • 4203 Health services and systems
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Oyedeji, C. I., Hall, K., Luciano, A., Morey, M. C., & Strouse, J. J. (2020). Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study. Pilot Feasibility Stud, 6, 131. https://doi.org/10.1186/s40814-020-00673-3
Oyedeji, Charity I., Katherine Hall, Alison Luciano, Miriam C. Morey, and John J. Strouse. “Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study.Pilot Feasibility Stud 6 (2020): 131. https://doi.org/10.1186/s40814-020-00673-3.
Oyedeji CI, Hall K, Luciano A, Morey MC, Strouse JJ. Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study. Pilot Feasibility Stud. 2020;6:131.
Oyedeji, Charity I., et al. “Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study.Pilot Feasibility Stud, vol. 6, 2020, p. 131. Pubmed, doi:10.1186/s40814-020-00673-3.
Oyedeji CI, Hall K, Luciano A, Morey MC, Strouse JJ. Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study. Pilot Feasibility Stud. 2020;6:131.
Journal cover image

Published In

Pilot Feasibility Stud

DOI

ISSN

2055-5784

Publication Date

2020

Volume

6

Start / End Page

131

Location

England

Related Subject Headings

  • 4203 Health services and systems