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Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study.

Publication ,  Journal Article
Murphy, SL; Mahan, JD; Troost, JP; Srivastava, T; Kogon, AJ; Cai, Y; Davis, TK; Fernandez, H; Fornoni, A; Gbadegesin, RA; Herreshoff, E ...
Published in: Kidney Int Rep
October 2020

INTRODUCTION: Prior cross-sectional studies suggest that health-related quality of life (HRQOL) worsens with more severe glomerular disease. This longitudinal analysis was conducted to assess changes in HRQOL with changing disease status. METHODS: Cure Glomerulonephropathy (CureGN) is a cohort of patients with minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, IgA vasculitis, or IgA nephropathy. HRQOL was assessed at enrollment and follow-up visits 1 to 3 times annually for up to 5 years with the Patient-Reported Outcomes Measurement Information System (PROMIS). Global health, anxiety, and fatigue domains were measured in all; mobility was measured in children; and sleep-related impairment was measured in adults. Linear mixed effects models were used to evaluate HRQOL responsiveness to changes in disease status. RESULTS: A total of 469 children and 1146 adults with PROMIS scores were included in the analysis. HRQOL improved over time in nearly all domains, though group-level changes were modest. Edema was most consistently associated with worse HRQOL across domains among children and adults. A greater number of symptoms also predicted worse HRQOL in all domains. Sex, age, obesity, and serum albumin were associated with some HRQOL domains. The estimated glomerular filtration rate (eGFR) was only associated with fatigue and adult physical health; proteinuria was not associated with any HRQOL domain in adjusted models. CONCLUSION: HRQOL measures were responsive to changes in disease activity, as indicated by edema. HRQOL over time was not predicted by laboratory-based markers of disease. Patient-reported edema and number of symptoms were the strongest predictors of HRQOL, highlighting the importance of the patient experience in glomerular disease. HRQOL outcomes inform understanding of the patient experience for children and adults with glomerular diseases.

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Published In

Kidney Int Rep

DOI

EISSN

2468-0249

Publication Date

October 2020

Volume

5

Issue

10

Start / End Page

1679 / 1689

Location

United States

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Murphy, S. L., Mahan, J. D., Troost, J. P., Srivastava, T., Kogon, A. J., Cai, Y., … CureGN Consortium, . (2020). Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study. Kidney Int Rep, 5(10), 1679–1689. https://doi.org/10.1016/j.ekir.2020.06.041
Murphy, Shannon L., John D. Mahan, Jonathan P. Troost, Tarak Srivastava, Amy J. Kogon, Yi Cai, T Keefe Davis, et al. “Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study.Kidney Int Rep 5, no. 10 (October 2020): 1679–89. https://doi.org/10.1016/j.ekir.2020.06.041.
Murphy SL, Mahan JD, Troost JP, Srivastava T, Kogon AJ, Cai Y, et al. Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study. Kidney Int Rep. 2020 Oct;5(10):1679–89.
Murphy, Shannon L., et al. “Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study.Kidney Int Rep, vol. 5, no. 10, Oct. 2020, pp. 1679–89. Pubmed, doi:10.1016/j.ekir.2020.06.041.
Murphy SL, Mahan JD, Troost JP, Srivastava T, Kogon AJ, Cai Y, Davis TK, Fernandez H, Fornoni A, Gbadegesin RA, Herreshoff E, Canetta PA, Nachman PH, Reeve BB, Selewski DT, Sethna CB, Wang C-S, Bartosh SM, Gipson DS, Tuttle KR, CureGN Consortium. Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study. Kidney Int Rep. 2020 Oct;5(10):1679–1689.
Journal cover image

Published In

Kidney Int Rep

DOI

EISSN

2468-0249

Publication Date

October 2020

Volume

5

Issue

10

Start / End Page

1679 / 1689

Location

United States

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences