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Is cardiovascular fitness associated with structural brain integrity in midlife? Evidence from a population-representative birth cohort study.

Publication ,  Journal Article
d'Arbeloff, T; Cooke, M; Knodt, AR; Sison, M; Melzer, TR; Ireland, D; Poulton, R; Ramrakha, S; Moffitt, TE; Caspi, A; Hariri, AR
Published in: Aging
October 2020

Improving cardiovascular fitness may buffer against age-related cognitive decline and mitigate dementia risk by staving off brain atrophy. However, it is unclear if such effects reflect factors operating in childhood (neuroselection) or adulthood (neuroprotection). Using data from 807 members of the Dunedin Study, a population-representative birth cohort, we investigated associations between cardiovascular fitness and structural brain integrity at age 45, and the extent to which associations reflected possible neuroselection or neuroprotection by controlling for childhood IQ. Higher fitness, as indexed by VO2Max, was not associated with average cortical thickness, total surface area, or subcortical gray matter volume including the hippocampus. However, higher fitness was associated with thicker cortex in prefrontal and temporal regions as well as greater cerebellar gray matter volume. Higher fitness was also associated with decreased hippocampal fissure volume. These associations were unaffected by the inclusion of childhood IQ in analyses. In contrast, a higher rate of decline in cardiovascular fitness from 26 to 45 years was not robustly associated with structural brain integrity. Our findings are consistent with a neuroprotective account of adult cardiovascular fitness but suggest that effects are not uniformly observed across the brain and reflect contemporaneous fitness more so than decline over time.

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Published In

Aging

DOI

EISSN

1945-4589

ISSN

1945-4589

Publication Date

October 2020

Volume

12

Issue

20

Start / End Page

20888 / 20914

Related Subject Headings

  • Male
  • Humans
  • Female
  • Developmental Biology
  • Cohort Studies
  • Cardiovascular Physiological Phenomena
  • Cardiorespiratory Fitness
  • Brain
  • Age Factors
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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d’Arbeloff, T., Cooke, M., Knodt, A. R., Sison, M., Melzer, T. R., Ireland, D., … Hariri, A. R. (2020). Is cardiovascular fitness associated with structural brain integrity in midlife? Evidence from a population-representative birth cohort study. Aging, 12(20), 20888–20914. https://doi.org/10.18632/aging.104112
Arbeloff, Tracy d’, Megan Cooke, Annchen R. Knodt, Maria Sison, Tracy R. Melzer, David Ireland, Richie Poulton, et al. “Is cardiovascular fitness associated with structural brain integrity in midlife? Evidence from a population-representative birth cohort study.Aging 12, no. 20 (October 2020): 20888–914. https://doi.org/10.18632/aging.104112.
d’Arbeloff T, Cooke M, Knodt AR, Sison M, Melzer TR, Ireland D, et al. Is cardiovascular fitness associated with structural brain integrity in midlife? Evidence from a population-representative birth cohort study. Aging. 2020 Oct;12(20):20888–914.
d’Arbeloff, Tracy, et al. “Is cardiovascular fitness associated with structural brain integrity in midlife? Evidence from a population-representative birth cohort study.Aging, vol. 12, no. 20, Oct. 2020, pp. 20888–914. Epmc, doi:10.18632/aging.104112.
d’Arbeloff T, Cooke M, Knodt AR, Sison M, Melzer TR, Ireland D, Poulton R, Ramrakha S, Moffitt TE, Caspi A, Hariri AR. Is cardiovascular fitness associated with structural brain integrity in midlife? Evidence from a population-representative birth cohort study. Aging. 2020 Oct;12(20):20888–20914.

Published In

Aging

DOI

EISSN

1945-4589

ISSN

1945-4589

Publication Date

October 2020

Volume

12

Issue

20

Start / End Page

20888 / 20914

Related Subject Headings

  • Male
  • Humans
  • Female
  • Developmental Biology
  • Cohort Studies
  • Cardiovascular Physiological Phenomena
  • Cardiorespiratory Fitness
  • Brain
  • Age Factors
  • 1112 Oncology and Carcinogenesis