Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.
Publication
, Journal Article
Otsuki, K; Zhang, M; Yamamoto, A; Tsuji, M; Tejima, M; Bai, Z-S; Zhou, D; Huang, L; Chen, C-H; Lee, K-H; Li, N; Li, W; Koike, K
Published in: J Nat Prod
December 24, 2020
During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A-C (1-3)] and three known tigliane diterpenoids (4-6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds (4 and 6) showed potent anti-HIV activity with IC50 values of 3.8 and 12.8 nM, respectively.
Duke Scholars
Published In
J Nat Prod
DOI
EISSN
1520-6025
Publication Date
December 24, 2020
Volume
83
Issue
12
Start / End Page
3584 / 3590
Location
United States
Related Subject Headings
- Wikstroemia
- Spectrum Analysis
- Phorbols
- Medicinal & Biomolecular Chemistry
- Humans
- Diterpenes
- Cell Line
- Anti-HIV Agents
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Otsuki, K., Zhang, M., Yamamoto, A., Tsuji, M., Tejima, M., Bai, Z.-S., … Koike, K. (2020). Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla. J Nat Prod, 83(12), 3584–3590. https://doi.org/10.1021/acs.jnatprod.0c00700
Otsuki, Kouharu, Mi Zhang, Asuka Yamamoto, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, et al. “Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.” J Nat Prod 83, no. 12 (December 24, 2020): 3584–90. https://doi.org/10.1021/acs.jnatprod.0c00700.
Otsuki K, Zhang M, Yamamoto A, Tsuji M, Tejima M, Bai Z-S, et al. Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla. J Nat Prod. 2020 Dec 24;83(12):3584–90.
Otsuki, Kouharu, et al. “Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.” J Nat Prod, vol. 83, no. 12, Dec. 2020, pp. 3584–90. Pubmed, doi:10.1021/acs.jnatprod.0c00700.
Otsuki K, Zhang M, Yamamoto A, Tsuji M, Tejima M, Bai Z-S, Zhou D, Huang L, Chen C-H, Lee K-H, Li N, Li W, Koike K. Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla. J Nat Prod. 2020 Dec 24;83(12):3584–3590.
Published In
J Nat Prod
DOI
EISSN
1520-6025
Publication Date
December 24, 2020
Volume
83
Issue
12
Start / End Page
3584 / 3590
Location
United States
Related Subject Headings
- Wikstroemia
- Spectrum Analysis
- Phorbols
- Medicinal & Biomolecular Chemistry
- Humans
- Diterpenes
- Cell Line
- Anti-HIV Agents
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences