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Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.

Publication ,  Journal Article
Griffin, DR; Archang, MM; Kuan, C-H; Weaver, WM; Weinstein, JS; Feng, AC; Ruccia, A; Sideris, E; Ragkousis, V; Koh, J; Plikus, MV; Di Carlo, D ...
Published in: Nat Mater
April 2021

Microporous annealed particle (MAP) scaffolds are flowable, in situ crosslinked, microporous scaffolds composed of microgel building blocks and were previously shown to accelerate wound healing. To promote more extensive tissue ingrowth before scaffold degradation, we aimed to slow MAP degradation by switching the chirality of the crosslinking peptides from L- to D-amino acids. Unexpectedly, despite showing the predicted slower enzymatic degradation in vitro, D-peptide crosslinked MAP hydrogel (D-MAP) hastened material degradation in vivo and imparted significant tissue regeneration to healed cutaneous wounds, including increased tensile strength and hair neogenesis. MAP scaffolds recruit IL-33 type 2 myeloid cells, which is amplified in the presence of D-peptides. Remarkably, D-MAP elicited significant antigen-specific immunity against the D-chiral peptides, and an intact adaptive immune system was required for the hydrogel-induced skin regeneration. These findings demonstrate that the generation of an adaptive immune response from a biomaterial is sufficient to induce cutaneous regenerative healing despite faster scaffold degradation.

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Published In

Nat Mater

DOI

EISSN

1476-4660

Publication Date

April 2021

Volume

20

Issue

4

Start / End Page

560 / 569

Location

England

Related Subject Headings

  • Wound Healing
  • Tissue Scaffolds
  • Skin
  • Regeneration
  • Porosity
  • Nanoscience & Nanotechnology
  • Mice
  • Interleukin-33
  • Hydrogels
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Griffin, D. R., Archang, M. M., Kuan, C.-H., Weaver, W. M., Weinstein, J. S., Feng, A. C., … Scumpia, P. O. (2021). Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing. Nat Mater, 20(4), 560–569. https://doi.org/10.1038/s41563-020-00844-w
Griffin, Donald R., Maani M. Archang, Chen-Hsiang Kuan, Westbrook M. Weaver, Jason S. Weinstein, An Chieh Feng, Amber Ruccia, et al. “Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.Nat Mater 20, no. 4 (April 2021): 560–69. https://doi.org/10.1038/s41563-020-00844-w.
Griffin DR, Archang MM, Kuan C-H, Weaver WM, Weinstein JS, Feng AC, et al. Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing. Nat Mater. 2021 Apr;20(4):560–9.
Griffin, Donald R., et al. “Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.Nat Mater, vol. 20, no. 4, Apr. 2021, pp. 560–69. Pubmed, doi:10.1038/s41563-020-00844-w.
Griffin DR, Archang MM, Kuan C-H, Weaver WM, Weinstein JS, Feng AC, Ruccia A, Sideris E, Ragkousis V, Koh J, Plikus MV, Di Carlo D, Segura T, Scumpia PO. Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing. Nat Mater. 2021 Apr;20(4):560–569.

Published In

Nat Mater

DOI

EISSN

1476-4660

Publication Date

April 2021

Volume

20

Issue

4

Start / End Page

560 / 569

Location

England

Related Subject Headings

  • Wound Healing
  • Tissue Scaffolds
  • Skin
  • Regeneration
  • Porosity
  • Nanoscience & Nanotechnology
  • Mice
  • Interleukin-33
  • Hydrogels
  • Female