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Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.

Publication ,  Journal Article
da Silveira, WA; Fazelinia, H; Rosenthal, SB; Laiakis, EC; Kim, MS; Meydan, C; Kidane, Y; Rathi, KS; Smith, SM; Stear, B; Ying, Y; Zhang, Y ...
Published in: Cell
November 25, 2020

Spaceflight is known to impose changes on human physiology with unknown molecular etiologies. To reveal these causes, we used a multi-omics, systems biology analytical approach using biomedical profiles from fifty-nine astronauts and data from NASA's GeneLab derived from hundreds of samples flown in space to determine transcriptomic, proteomic, metabolomic, and epigenetic responses to spaceflight. Overall pathway analyses on the multi-omics datasets showed significant enrichment for mitochondrial processes, as well as innate immunity, chronic inflammation, cell cycle, circadian rhythm, and olfactory functions. Importantly, NASA's Twin Study provided a platform to confirm several of our principal findings. Evidence of altered mitochondrial function and DNA damage was also found in the urine and blood metabolic data compiled from the astronaut cohort and NASA Twin Study data, indicating mitochondrial stress as a consistent phenotype of spaceflight.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

November 25, 2020

Volume

183

Issue

5

Start / End Page

1185 / 1201.e20

Location

United States

Related Subject Headings

  • Stress, Physiological
  • Space Flight
  • Smell
  • Organ Specificity
  • Muscles
  • Mitochondria
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Metabolic Flux Analysis
  • Lipid Metabolism
 

Citation

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da Silveira, W. A., Fazelinia, H., Rosenthal, S. B., Laiakis, E. C., Kim, M. S., Meydan, C., … Beheshti, A. (2020). Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. Cell, 183(5), 1185-1201.e20. https://doi.org/10.1016/j.cell.2020.11.002
Silveira, Willian A. da, Hossein Fazelinia, Sara Brin Rosenthal, Evagelia C. Laiakis, Man S. Kim, Cem Meydan, Yared Kidane, et al. “Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.Cell 183, no. 5 (November 25, 2020): 1185-1201.e20. https://doi.org/10.1016/j.cell.2020.11.002.
da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, et al. Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. Cell. 2020 Nov 25;183(5):1185-1201.e20.
da Silveira, Willian A., et al. “Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.Cell, vol. 183, no. 5, Nov. 2020, pp. 1185-1201.e20. Pubmed, doi:10.1016/j.cell.2020.11.002.
da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, Kidane Y, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian B, Wang D, Nugent A, Costa HA, Zwart SR, Schrepfer S, Elworth RAL, Sapoval N, Treangen T, MacKay M, Gokhale NS, Horner SM, Singh LN, Wallace DC, Willey JS, Schisler JC, Meller R, McDonald JT, Fisch KM, Hardiman G, Taylor D, Mason CE, Costes SV, Beheshti A. Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. Cell. 2020 Nov 25;183(5):1185-1201.e20.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

November 25, 2020

Volume

183

Issue

5

Start / End Page

1185 / 1201.e20

Location

United States

Related Subject Headings

  • Stress, Physiological
  • Space Flight
  • Smell
  • Organ Specificity
  • Muscles
  • Mitochondria
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Metabolic Flux Analysis
  • Lipid Metabolism