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The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels.

Publication ,  Journal Article
Dong, K; Du, Y; Rinkevich, F; Wang, L; Xu, P
Published in: Pesticide biochemistry and physiology
May 2015

It has been nearly three decades since the identification of the Drosophila Sodium Channel 1 (DSC1) gene from Drosophila melanogaster. The orthologs of the DSC1 gene have now been identified in other insect species including BSC1 from Blattella germanica. Functional analyses of DSC1/BSC1 channels in Xenopus oocytes reveal that DSC1 and BSC1 encode voltage-gated cation channels that are more permeable to Ca(2+) than to Na(+). Genetic and electrophysiological analyses show that knockout of the DSC1 gene in D. melanogaster causes behavioral and neurological modifications. In this review, we summarize major findings from recent studies and highlight a unique role of the DSC1 channel, distinct from that of the sodium channel, in regulating membrane excitability and modulating toxicity of pyrethroid insecticides.

Duke Scholars

Published In

Pesticide biochemistry and physiology

DOI

EISSN

1095-9939

ISSN

0048-3575

Publication Date

May 2015

Volume

120

Start / End Page

36 / 39

Related Subject Headings

  • Sodium Channels
  • Pyrethrins
  • Insecticides
  • Insecticide Resistance
  • Insect Proteins
  • Entomology
  • Animals
  • 31 Biological sciences
  • 30 Agricultural, veterinary and food sciences
  • 07 Agricultural and Veterinary Sciences
 

Citation

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Dong, K., Du, Y., Rinkevich, F., Wang, L., & Xu, P. (2015). The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. Pesticide Biochemistry and Physiology, 120, 36–39. https://doi.org/10.1016/j.pestbp.2014.12.005
Dong, Ke, Yuzhe Du, Frank Rinkevich, Lingxin Wang, and Peng Xu. “The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels.Pesticide Biochemistry and Physiology 120 (May 2015): 36–39. https://doi.org/10.1016/j.pestbp.2014.12.005.
Dong K, Du Y, Rinkevich F, Wang L, Xu P. The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. Pesticide biochemistry and physiology. 2015 May;120:36–9.
Dong, Ke, et al. “The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels.Pesticide Biochemistry and Physiology, vol. 120, May 2015, pp. 36–39. Epmc, doi:10.1016/j.pestbp.2014.12.005.
Dong K, Du Y, Rinkevich F, Wang L, Xu P. The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. Pesticide biochemistry and physiology. 2015 May;120:36–39.
Journal cover image

Published In

Pesticide biochemistry and physiology

DOI

EISSN

1095-9939

ISSN

0048-3575

Publication Date

May 2015

Volume

120

Start / End Page

36 / 39

Related Subject Headings

  • Sodium Channels
  • Pyrethrins
  • Insecticides
  • Insecticide Resistance
  • Insect Proteins
  • Entomology
  • Animals
  • 31 Biological sciences
  • 30 Agricultural, veterinary and food sciences
  • 07 Agricultural and Veterinary Sciences