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Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides.

Publication ,  Journal Article
Liu, Z; Valles, SM; Dong, K
Published in: Insect biochemistry and molecular biology
October 2000

Knockdown resistance (kdr) to pyrethroid insecticides has been attributed to point mutations in the para sodium channel gene in more than a half dozen insect pest species. In this study, we identified two novel para mutations in five highly resistant kdr-type German cockroach strains. The two mutations, from glutamic acid (E434) to lysine (K434) and from cysteine (C764) to arginine (R764), respectively, are located in the first intracellular linker connecting domains I and II. E434K is located near the beginning of the linker (closest to domain I), whereas C764R is found toward the end of the linker (closest to domain II). Two additional mutations from aspartic acid (D58) to glycine (G58), and from proline (P1880) to leucine (L1888), respectively, were found in one of the resistant strains. The four mutations coexist with the previously identified leucine to phenylalanine (L993F) kdr mutation in IIS6, and are present only in the highly resistant individuals of a given strain. These findings suggest that these mutations might be responsible for high levels of knockdown resistance toward pyrethroid insecticides in the German cockroach.

Duke Scholars

Published In

Insect biochemistry and molecular biology

DOI

EISSN

1879-0240

ISSN

0965-1748

Publication Date

October 2000

Volume

30

Issue

10

Start / End Page

991 / 997

Related Subject Headings

  • Sodium Channels
  • Pyrethrins
  • Point Mutation
  • Molecular Sequence Data
  • Insecticide Resistance
  • Humans
  • Entomology
  • Blattellidae
  • Animals
  • Amino Acid Sequence
 

Citation

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Liu, Z., Valles, S. M., & Dong, K. (2000). Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides. Insect Biochemistry and Molecular Biology, 30(10), 991–997. https://doi.org/10.1016/s0965-1748(00)00074-6
Liu, Z., S. M. Valles, and K. Dong. “Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides.Insect Biochemistry and Molecular Biology 30, no. 10 (October 2000): 991–97. https://doi.org/10.1016/s0965-1748(00)00074-6.
Liu, Z., et al. “Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides.Insect Biochemistry and Molecular Biology, vol. 30, no. 10, Oct. 2000, pp. 991–97. Epmc, doi:10.1016/s0965-1748(00)00074-6.
Journal cover image

Published In

Insect biochemistry and molecular biology

DOI

EISSN

1879-0240

ISSN

0965-1748

Publication Date

October 2000

Volume

30

Issue

10

Start / End Page

991 / 997

Related Subject Headings

  • Sodium Channels
  • Pyrethrins
  • Point Mutation
  • Molecular Sequence Data
  • Insecticide Resistance
  • Humans
  • Entomology
  • Blattellidae
  • Animals
  • Amino Acid Sequence