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A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.

Publication ,  Journal Article
Xiao, X; Deng, H; Furlan, A; Yang, T; Zhang, X; Hwang, G-R; Tucciarone, J; Wu, P; He, M; Palaniswamy, R; Ramakrishnan, C; Ritola, K; Osten, P ...
Published in: Cell
October 2020

The striosome compartment within the dorsal striatum has been implicated in reinforcement learning and regulation of motivation, but how striosomal neurons contribute to these functions remains elusive. Here, we show that a genetically identified striosomal population, which expresses the Teashirt family zinc finger 1 (Tshz1) and belongs to the direct pathway, drives negative reinforcement and is essential for aversive learning in mice. Contrasting a "conventional" striosomal direct pathway, the Tshz1 neurons cause aversion, movement suppression, and negative reinforcement once activated, and they receive a distinct set of synaptic inputs. These neurons are predominantly excited by punishment rather than reward and represent the anticipation of punishment or the motivation for avoidance. Furthermore, inhibiting these neurons impairs punishment-based learning without affecting reward learning or movement. These results establish a major role of striosomal neurons in behaviors reinforced by punishment and moreover uncover functions of the direct pathway unaccounted for in classic models.

Duke Scholars

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Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

October 2020

Volume

183

Issue

1

Start / End Page

211 / 227.e20

Related Subject Headings

  • Repressor Proteins
  • Reinforcement, Psychology
  • Punishment
  • Neurons
  • Motivation
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Learning
 

Citation

APA
Chicago
ICMJE
MLA
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Xiao, X., Deng, H., Furlan, A., Yang, T., Zhang, X., Hwang, G.-R., … Li, B. (2020). A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement. Cell, 183(1), 211-227.e20. https://doi.org/10.1016/j.cell.2020.08.032
Xiao, Xiong, Hanfei Deng, Alessandro Furlan, Tao Yang, Xian Zhang, Ga-Ram Hwang, Jason Tucciarone, et al. “A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.Cell 183, no. 1 (October 2020): 211-227.e20. https://doi.org/10.1016/j.cell.2020.08.032.
Xiao X, Deng H, Furlan A, Yang T, Zhang X, Hwang G-R, et al. A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement. Cell. 2020 Oct;183(1):211-227.e20.
Xiao, Xiong, et al. “A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.Cell, vol. 183, no. 1, Oct. 2020, pp. 211-227.e20. Epmc, doi:10.1016/j.cell.2020.08.032.
Xiao X, Deng H, Furlan A, Yang T, Zhang X, Hwang G-R, Tucciarone J, Wu P, He M, Palaniswamy R, Ramakrishnan C, Ritola K, Hantman A, Deisseroth K, Osten P, Huang ZJ, Li B. A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement. Cell. 2020 Oct;183(1):211-227.e20.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

October 2020

Volume

183

Issue

1

Start / End Page

211 / 227.e20

Related Subject Headings

  • Repressor Proteins
  • Reinforcement, Psychology
  • Punishment
  • Neurons
  • Motivation
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Learning