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Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.

Publication ,  Journal Article
Kline, EM; Houser, MC; Herrick, MK; Seibler, P; Klein, C; West, A; Tansey, MG
Published in: Mov Disord
January 2021

Idiopathic Parkinson's disease (iPD) is a movement disorder characterized by the degeneration of dopaminergic neurons and aggregation of the protein α-synuclein. Patients with iPD vary in age of symptom onset, rate of progression, severity of motor and non-motor symptoms, and extent of central and peripheral inflammation. Genetic and environmental factors are believed to act synergistically in iPD pathogenesis. We propose that environmental factors (pesticides and infections) increase the risk for iPD via the immune system and that the role of PD risk genes in immune cells is worthy of investigation. This review highlights the major PD-relevant genes expressed in immune cells and key environmental factors that activate immune cells and, alone or in combination with other factors, may contribute to iPD pathogenesis. By reviewing these interactions, we seek to enable the future development of immunomodulatory approaches to prevent or delay onset of iPD. © 2020 International Parkinson and Movement Disorder Society.

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Published In

Mov Disord

DOI

EISSN

1531-8257

Publication Date

January 2021

Volume

36

Issue

1

Start / End Page

25 / 36

Location

United States

Related Subject Headings

  • alpha-Synuclein
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Inflammation
  • Immunity
  • Humans
  • Dopaminergic Neurons
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
 

Citation

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Kline, E. M., Houser, M. C., Herrick, M. K., Seibler, P., Klein, C., West, A., & Tansey, M. G. (2021). Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation. Mov Disord, 36(1), 25–36. https://doi.org/10.1002/mds.28411
Kline, Elizabeth M., Madelyn C. Houser, Mary K. Herrick, Philip Seibler, Christine Klein, Andrew West, and Malú G. Tansey. “Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.Mov Disord 36, no. 1 (January 2021): 25–36. https://doi.org/10.1002/mds.28411.
Kline EM, Houser MC, Herrick MK, Seibler P, Klein C, West A, et al. Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation. Mov Disord. 2021 Jan;36(1):25–36.
Kline, Elizabeth M., et al. “Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation.Mov Disord, vol. 36, no. 1, Jan. 2021, pp. 25–36. Pubmed, doi:10.1002/mds.28411.
Kline EM, Houser MC, Herrick MK, Seibler P, Klein C, West A, Tansey MG. Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation. Mov Disord. 2021 Jan;36(1):25–36.
Journal cover image

Published In

Mov Disord

DOI

EISSN

1531-8257

Publication Date

January 2021

Volume

36

Issue

1

Start / End Page

25 / 36

Location

United States

Related Subject Headings

  • alpha-Synuclein
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Inflammation
  • Immunity
  • Humans
  • Dopaminergic Neurons
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences