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Biomaterials-Mediated Regulation of Macrophage Cell Fate.

Publication ,  Journal Article
Liu, Y; Segura, T
Published in: Frontiers in bioengineering and biotechnology
January 2020

Endogenous regeneration aims to rebuild and reinstate tissue function through enlisting natural self-repairing processes. Promoting endogenous regeneration by reducing tissue-damaging inflammatory responses while reinforcing self-resolving inflammatory processes is gaining popularity. In this approach, the immune system is recruited as the principal player to deposit a pro-reparative matrix and secrete pro-regenerative cytokines and growth factors. The natural wound healing cascade involves many immune system players (neutrophils, macrophages, T cells, B cells, etc.) that are likely to play important and indispensable roles in endogenous regeneration. These cells support both the innate and adaptive arms of the immune system and collectively orchestrate host responses to tissue damage. As the early responders during the innate immune response, macrophages have been studied for decades in the context of inflammatory and foreign body responses and were often considered a cell type to be avoided. The view on macrophages has evolved and it is now understood that macrophages should be directly engaged, and their phenotype modulated, to guide the timely transition of the immune response and reparative environment. One way to achieve this is to design immunomodulating biomaterials that can be placed where endogenous regeneration is desired and actively direct macrophage polarization. Upon encountering these biomaterials, macrophages are trained to perform more pro-regenerative roles and generate the appropriate environment for later stages of regeneration since they bridge the innate immune response and the adaptive immune response. This new design paradigm necessitates the understanding of how material design elicits differential macrophage phenotype activation. This review is focused on the macrophage-material interaction and how to engineer biomaterials to steer macrophage phenotypes for better tissue regeneration.

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Published In

Frontiers in bioengineering and biotechnology

DOI

EISSN

2296-4185

ISSN

2296-4185

Publication Date

January 2020

Volume

8

Start / End Page

609297

Related Subject Headings

  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 1004 Medical Biotechnology
  • 0903 Biomedical Engineering
  • 0699 Other Biological Sciences
 

Citation

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ICMJE
MLA
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Liu, Y., & Segura, T. (2020). Biomaterials-Mediated Regulation of Macrophage Cell Fate. Frontiers in Bioengineering and Biotechnology, 8, 609297. https://doi.org/10.3389/fbioe.2020.609297
Liu, Yining, and Tatiana Segura. “Biomaterials-Mediated Regulation of Macrophage Cell Fate.Frontiers in Bioengineering and Biotechnology 8 (January 2020): 609297. https://doi.org/10.3389/fbioe.2020.609297.
Liu Y, Segura T. Biomaterials-Mediated Regulation of Macrophage Cell Fate. Frontiers in bioengineering and biotechnology. 2020 Jan;8:609297.
Liu, Yining, and Tatiana Segura. “Biomaterials-Mediated Regulation of Macrophage Cell Fate.Frontiers in Bioengineering and Biotechnology, vol. 8, Jan. 2020, p. 609297. Epmc, doi:10.3389/fbioe.2020.609297.
Liu Y, Segura T. Biomaterials-Mediated Regulation of Macrophage Cell Fate. Frontiers in bioengineering and biotechnology. 2020 Jan;8:609297.

Published In

Frontiers in bioengineering and biotechnology

DOI

EISSN

2296-4185

ISSN

2296-4185

Publication Date

January 2020

Volume

8

Start / End Page

609297

Related Subject Headings

  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 1004 Medical Biotechnology
  • 0903 Biomedical Engineering
  • 0699 Other Biological Sciences