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State-dependent bioelectronic interface to control bladder function.

Publication ,  Journal Article
Hokanson, JA; Langdale, CL; Sridhar, A; Milliken, P; Grill, WM
Published in: Scientific reports
January 2021

Electrical stimulation therapies to promote bladder filling and prevent incontinence deliver continuous inhibitory stimulation, even during bladder emptying. However, continuous inhibitory stimulation that increases bladder capacity (BC) can reduce the efficiency of subsequent voiding (VE). Here we demonstrate that state-dependent stimulation, with different electrical stimulation parameters delivered during filling and emptying can increase both BC and VE relative to continuous stimulation in rats and cats of both sexes. We show that continuous 10 Hz pudendal nerve stimulation increased BC (120-180% of control) but decreased VE (12-71%, relative to control). In addition to increasing BC, state-dependent stimulation in both rats and cats increased VE (280-759% relative to continuous stimulation); motor bursting in cats increased VE beyond the control (no stimulation) condition (males: 323%; females: 161%). These results suggest that a bioelectronic bladder pacemaker can treat complex voiding disorders, including both incontinence and retention, which paradoxically are often present in the same individual.

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Published In

Scientific reports

DOI

EISSN

2045-2322

ISSN

2045-2322

Publication Date

January 2021

Volume

11

Issue

1

Start / End Page

314

Related Subject Headings

  • Urination
  • Urinary Bladder
  • Rats
  • Muscle Contraction
  • Male
  • Female
  • Electric Stimulation
  • Animals
 

Citation

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Hokanson, J. A., Langdale, C. L., Sridhar, A., Milliken, P., & Grill, W. M. (2021). State-dependent bioelectronic interface to control bladder function. Scientific Reports, 11(1), 314. https://doi.org/10.1038/s41598-020-79493-7
Hokanson, James A., Christopher L. Langdale, Arun Sridhar, Phil Milliken, and Warren M. Grill. “State-dependent bioelectronic interface to control bladder function.Scientific Reports 11, no. 1 (January 2021): 314. https://doi.org/10.1038/s41598-020-79493-7.
Hokanson JA, Langdale CL, Sridhar A, Milliken P, Grill WM. State-dependent bioelectronic interface to control bladder function. Scientific reports. 2021 Jan;11(1):314.
Hokanson, James A., et al. “State-dependent bioelectronic interface to control bladder function.Scientific Reports, vol. 11, no. 1, Jan. 2021, p. 314. Epmc, doi:10.1038/s41598-020-79493-7.
Hokanson JA, Langdale CL, Sridhar A, Milliken P, Grill WM. State-dependent bioelectronic interface to control bladder function. Scientific reports. 2021 Jan;11(1):314.

Published In

Scientific reports

DOI

EISSN

2045-2322

ISSN

2045-2322

Publication Date

January 2021

Volume

11

Issue

1

Start / End Page

314

Related Subject Headings

  • Urination
  • Urinary Bladder
  • Rats
  • Muscle Contraction
  • Male
  • Female
  • Electric Stimulation
  • Animals