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Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction.

Publication ,  Journal Article
Demange, PA; Malanchini, M; Mallard, TT; Biroli, P; Cox, SR; Grotzinger, AD; Tucker-Drob, EM; Abdellaoui, A; Arseneault, L; van Bergen, E ...
Published in: Nature genetics
January 2021

Little is known about the genetic architecture of traits affecting educational attainment other than cognitive ability. We used genomic structural equation modeling and prior genome-wide association studies (GWASs) of educational attainment (n = 1,131,881) and cognitive test performance (n = 257,841) to estimate SNP associations with educational attainment variation that is independent of cognitive ability. We identified 157 genome-wide-significant loci and a polygenic architecture accounting for 57% of genetic variance in educational attainment. Noncognitive genetics were enriched in the same brain tissues and cell types as cognitive performance, but showed different associations with gray-matter brain volumes. Noncognitive genetics were further distinguished by associations with personality traits, less risky behavior and increased risk for certain psychiatric disorders. For socioeconomic success and longevity, noncognitive and cognitive-performance genetics demonstrated associations of similar magnitude. By conducting a GWAS of a phenotype that was not directly measured, we offer a view of genetic architecture of noncognitive skills influencing educational success.

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Published In

Nature genetics

DOI

EISSN

1546-1718

ISSN

1061-4036

Publication Date

January 2021

Volume

53

Issue

1

Start / End Page

35 / 44

Related Subject Headings

  • Risk-Taking
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Personality
  • Multifactorial Inheritance
  • Molecular Sequence Annotation
  • Models, Genetic
  • Mental Disorders
  • Intelligence
  • Humans
 

Citation

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Demange, P. A., Malanchini, M., Mallard, T. T., Biroli, P., Cox, S. R., Grotzinger, A. D., … Nivard, M. G. (2021). Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. Nature Genetics, 53(1), 35–44. https://doi.org/10.1038/s41588-020-00754-2
Demange, Perline A., Margherita Malanchini, Travis T. Mallard, Pietro Biroli, Simon R. Cox, Andrew D. Grotzinger, Elliot M. Tucker-Drob, et al. “Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction.Nature Genetics 53, no. 1 (January 2021): 35–44. https://doi.org/10.1038/s41588-020-00754-2.
Demange PA, Malanchini M, Mallard TT, Biroli P, Cox SR, Grotzinger AD, et al. Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. Nature genetics. 2021 Jan;53(1):35–44.
Demange, Perline A., et al. “Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction.Nature Genetics, vol. 53, no. 1, Jan. 2021, pp. 35–44. Epmc, doi:10.1038/s41588-020-00754-2.
Demange PA, Malanchini M, Mallard TT, Biroli P, Cox SR, Grotzinger AD, Tucker-Drob EM, Abdellaoui A, Arseneault L, van Bergen E, Boomsma DI, Caspi A, Corcoran DL, Domingue BW, Harris KM, Ip HF, Mitchell C, Moffitt TE, Poulton R, Prinz JA, Sugden K, Wertz J, Williams BS, de Zeeuw EL, Belsky DW, Harden KP, Nivard MG. Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. Nature genetics. 2021 Jan;53(1):35–44.

Published In

Nature genetics

DOI

EISSN

1546-1718

ISSN

1061-4036

Publication Date

January 2021

Volume

53

Issue

1

Start / End Page

35 / 44

Related Subject Headings

  • Risk-Taking
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Personality
  • Multifactorial Inheritance
  • Molecular Sequence Annotation
  • Models, Genetic
  • Mental Disorders
  • Intelligence
  • Humans